Video Experimental Relacionado

Updated: Nov 12, 2025

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

Las múltiples funciones de los anticuerpos de la leche materna

Caroline Atyeo¹, Galit Alter²

¹Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; PhD Program in Virology, Division of Medical Sciences, Harvard University, Boston, MA, USA.

|March 19, 2021

Resumen

Los anticuerpos maternos transferidos a través de la leche materna son cruciales para la inmunidad neonatal. Estos anticuerpos ayudan a prevenir infecciones y apoyan un microbioma intestinal saludable del bebé, contribuyendo al desarrollo del bebé.

Área de la Ciencia:

Inmunología
Salud neonatal
Investigación del microbioma

Sus antecedentes:

Los recién nacidos poseen sistemas inmunológicos inmaduros, dependiendo de la inmunidad materna para su protección.
Los anticuerpos maternos se transfieren a través de la placenta y la leche materna.
Se conoce el papel de la inmunoglobulina G (IgG) placentaria, pero los mecanismos y funciones de la transferencia de anticuerpos en la leche materna son menos conocidos.

Objetivo del estudio:

Explorar la importancia de los anticuerpos de la leche materna en la inmunidad neonatal.
Discutir los mecanismos de selección y transferencia de anticuerpos a través de la leche materna.
Destacar las funciones protectoras de los anticuerpos de la leche materna contra las enfermedades neonatales.

Principales métodos:

Revisión de la literatura científica emergente.
Análisis de los datos sobre la transferencia y función de anticuerpos.
Discusión de los mecanismos inmunológicos en el desarrollo neonatal.

Principales resultados:

Los anticuerpos de la leche materna desempeñan diversas funciones en la protección neonatal.
Son vitales para prevenir las infecciones en los recién nacidos.
Influyen en la selección de comensales intestinales y promueven la tolerancia inmune.

Conclusiones:

Los anticuerpos de la leche materna son esenciales para la defensa inmune neonatal.
Sus múltiples funciones favorecen la salud y el desarrollo de los niños.
Se necesita más investigación para aclarar plenamente sus mecanismos e impacto.

Más Videos Relacionados

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings

Published on: February 7, 2025

Videos de Conceptos Relacionados

Antibody Actions

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

Antibody Structure

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

Humoral Immune Responses

Humoral Immune Responses

Antibody Structure and Classes

Antibody Structure and Classes

Antibodies, also known as immunoglobulins, are produced by B cells in response to foreign substances, such as bacteria and viruses. These proteins are critical for recognizing and neutralizing these substances, protecting the body from potential harm.
The basic structure of an antibody consists of four protein chains: two identical heavy chains and two identical light chains. These chains are held together by disulfide bonds and other non-covalent interactions, forming a Y-shaped structure.

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...