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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
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Antivirales con objetivos comunes contra virus altamente patógenos
Lu Lu1, Shan Su1, Haitao Yang2
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
Cell
|March 19, 2021
Resumen
Los virus emergentes representan una amenaza constante. El desarrollo de antivirales de amplio espectro dirigidos a proteínas virales conservadas, como la ARN polimerasa dependiente del ARN, es crucial para la preparación para futuras epidemias.
Área de la Ciencia:
- Virología
- Descubrimiento de drogas
- Epidemiología
Sus antecedentes:
- Los virus emergentes han causado históricamente una mortalidad significativa.
- El cambio climático y la globalización aceleran la transmisión viral.
- Existe una necesidad de antivirales de amplio espectro contra objetivos virales conservados.
Objetivo del estudio:
- Revisar el desarrollo de antivirales con objetivos comunes.
- Identificar estrategias para combatir las amenazas virales emergentes y reemergentes.
- Para proporcionar ideas para el futuro desarrollo de fármacos antivirales.
Principales métodos:
- Revisión de la literatura sobre el desarrollo antiviral.
- Análisis de antivirales dirigidos a las proteínas virales conservadas.
- Examen de los antivirales dirigidos a las funciones virales comunes.
Principales resultados:
- Los antivirales dirigidos a las proteínas conservadas en diferentes virus son prometedores.
- Los compuestos dirigidos a la ARN polimerasa dependiente del ARN son un foco clave.
- El desarrollo de antivirales con objetivos compartidos ofrece una estrategia viable.
Conclusiones:
- La orientación a las proteínas virales conservadas es esencial para la actividad antiviral de amplio espectro.
- Los antivirales contra la ARN polimerasa dependiente del ARN son críticos para las epidemias futuras.
- Esta revisión proporciona una base para el desarrollo de nuevos antivirales contra los virus emergentes.
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