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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Video Experimental Relacionado

Updated: Nov 12, 2025

Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients
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La evolución del tumor

Ariana Huebner1, Michelle Dietzen1, Nicholas McGranahan1

  • 1Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, London, UK; Cancer Genome Evolution Research Group, University College London Cancer Institute, University College London, London, UK.

Cell
|March 19, 2021
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio introduce los conceptos de evolución del tumor, explicando cómo la comprensión del crecimiento del tumor y los cambios a lo largo del tiempo es clave para abordar los fracasos del tratamiento y la metástasis. Destaca la importancia de estudiar la progresión del tumor para desarrollar mejores terapias contra el cáncer.

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Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy
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Área de la Ciencia:

  • En el campo de la oncología
  • Biología del cáncer
  • Biología evolutiva

Sus antecedentes:

  • El crecimiento y la evolución del tumor son procesos complejos.
  • Comprender estos procesos es fundamental para el tratamiento eficaz del cáncer.
  • La evolución del tumor influye en la resistencia al tratamiento y la metástasis.

Objetivo del estudio:

  • Para proporcionar una comprensión fundamental de la evolución del tumor.
  • Introducir conceptos clave relacionados con la forma en que los tumores cambian con el tiempo.
  • Ofrecer información sobre los mecanismos detrás del fracaso del tratamiento y la metástasis.

Principales métodos:

  • Esto es una visión general introductoria, no un estudio de investigación.
  • Los conceptos clave se explican a través de un enfoque narrativo.
  • La información se presenta en formato PDF que se puede descargar.

Principales resultados:

  • La evolución del tumor implica cambios dinámicos en las células cancerosas.
  • Estos cambios pueden conducir al desarrollo de resistencia a los medicamentos.
  • Comprender la dinámica evolutiva es esencial para predecir el comportamiento del tumor.

Conclusiones:

  • La comprensión de la evolución del tumor es fundamental en la oncología.
  • La investigación adicional sobre la evolución del tumor puede mejorar los resultados de los pacientes.
  • Esta visión general sirve como punto de partida para comprender la progresión del cáncer.