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Updated: Nov 10, 2025
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Recording Mouse Ultrasonic Vocalizations to Evaluate Social Communication
Published on: June 5, 2016
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Escala flexible y persistencia de la comunicación social vocal
Jingyi Chen1,2, Jeffrey E Markowitz3, Varoth Lilascharoen4
1Department of Neuroscience, Scripps Research, La Jolla, CA, USA.
Nature
|April 1, 2021
Resumen
Los ratones escalan flexiblemente las vocalizaciones ultrasónicas (USV) para la comunicación social. Un nuevo circuito que involucra neuronas del área preóptica lateral (LPOA) desinhibe el gris periacueductal (PAG), controlando el volumen y la duración de la USV.
Área de la Ciencia:
- La neurociencia
- El comportamiento de los animales
- Las comunicaciones
Sus antecedentes:
- Las vocalizaciones son cruciales para la comunicación social entre especies.
- En los ratones, las vocalizaciones ultrasónicas de cortejo (USV) son desencadenadas por el olor femenino.
- Los mecanismos para el escalamiento flexible de la vocalización y el control neuronal siguen sin estar claros.
Objetivo del estudio:
- Investigar los circuitos neuronales que subyacen a la escala de vocalización flexible en ratones.
- Identificar las neuronas y vías específicas que controlan la amplitud y la duración de la vocalización ultrasónica.
- Comprender cómo el contexto social influye en los parámetros de la vocalización.
Principales métodos:
- Actividad optogenética de las neuronas del área preóptica lateral (LPOA) que expresan el receptor de estrógeno 1 (ESR1).
- Rastreo neuronal y grabaciones funcionales en el cerebro de ratón.
- Análisis de los parámetros de la vocalización ultrasónica (USV) (amplitud, duración) bajo diferentes condiciones de estimulación.
Principales resultados:
- La activación de las neuronas LPOA ESR1 provoca el repertorio completo de los VUS de cortejo.
- Un motivo de circuito desinhibidor: las neuronas LPOA inhiben las interneuronas grises periacueductal (PAG) locales, liberando neuronas USV.
- La activación de LPOA escala la amplitud de USV; la recuperación retardada de la inhibición prolonga los episodios de USV, lo que demuestra un control flexible.
Conclusiones:
- La vía de desinhibición LPOA-PAG permite un control flexible sobre el volumen y la duración del ataque.
- Este motivo de circuito es crítico para la comunicación social vocal adaptativa en ratones.
- Los hallazgos proporcionan información sobre la base neuronal de la flexibilidad vocal en los mamíferos.
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