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Un circuito de la amígdala que suprime el compromiso social

Jeong-Tae Kwon^1,2, Changhyeon Ryu^1,2, Hyeseung Lee^1,2,3

¹Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.

|April 1, 2021

Resumen

Los investigadores descubrieron una vía neuronal en ratones que suprime el apareamiento con hembras no saludables. Esto involucra a la amígdala cortical posteromedial (COApm) y la hormona liberadora de tirotropina (TRH), que es crucial para evaluar los riesgos sociales.

Área de la Ciencia:

La neurociencia
Biología del comportamiento
El comportamiento de los animales

Sus antecedentes:

Los comportamientos sociales innatos como el apareamiento son vitales pero conllevan riesgos.
Los mecanismos neuronales para evaluar y suprimir las interacciones sociales peligrosas son poco conocidos.

Objetivo del estudio:

Para identificar los circuitos neuronales que controlan la supresión del apareamiento con hembras no saludables.
Aclarar el papel de regiones cerebrales y neuromoduladores específicos en la evaluación del riesgo social.

Principales métodos:

Trazado anatómico e imágenes funcionales en ratones.
Análisis epistásico a nivel de circuito.
Manipulación de la actividad neuronal y la función del receptor.

Principales resultados:

El núcleo posteromedial de la amígdala cortical (COApm) es crítico para suprimir el apareamiento con hembras no saludables.
Las proyecciones de COApm a la amígdala medial (MEA) median esta supresión a través de la hormona liberadora de tirotropina (TRH).
La señalización de TRH en el MEA regula el comportamiento de apareamiento basado en el estado de salud de la hembra.

Conclusiones:

Una nueva vía neuronal que involucra COApm, MEA y TRH modula las interacciones sociales basadas en el estado de salud.
Este mecanismo permite a las personas equilibrar los costos sociales y los beneficios, evitando la propagación de enfermedades.
Las deficiencias en la selección de pareja pueden tener consecuencias significativas para la salud.

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