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Magnetismo, ultrasonido y nanotransportadores de sílice mesoporo estimulados por la luz para la teranosis y más allá
Fang-Chu Lin1,2, Yijun Xie1,2, Tian Deng1,2
1Department of Chemistry & Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.
Journal of the American Chemical Society
|April 15, 2021
Resumen
Las nanopartículas de sílice mesoporosa (MSN) que responden a estímulos ofrecen una administración e imágenes controladas de medicamentos. Esta revisión cubre los sistemas magnéticos, ultrasonidos y activados por luz, destacando los avances y desafíos para el uso clínico.
Área de la Ciencia:
- Nanotecnología
- Ciencias de los materiales
- Ingeniería biomédica
Sus antecedentes:
- Las nanopartículas de sílice mesoporosa (MSN) son ampliamente investigadas para aplicaciones biomédicas.
- Se han desarrollado varios sistemas de tapa de mesóporo para la liberación controlada de la carga.
- Las MSN sensibles a estímulos permiten la entrega bajo demanda de fármacos y agentes de imagen.
Objetivo del estudio:
- Estudio de las NMS sensibles a los estímulos activadas por estímulos biológicos externos no invasivos.
- Evaluar los diseños de límite, las ventajas y los inconvenientes de las diferentes plataformas de MSN.
- Para discutir los avances recientes, los mecanismos y los requisitos para la estimulación MSN.
Principales métodos:
- Revisión de la literatura sobre las MSN sensibles a los estímulos.
- Concentrarse en los sistemas que responden al magnetismo, ultrasonido y luz.
- Análisis de las estrategias de limitación de MSN y su rendimiento.
Principales resultados:
- Existen diversos sistemas de limitación de MSN, adaptados a estímulos específicos.
- El magnetismo, el ultrasonido y la luz ofrecen métodos de activación eficaces y no invasivos.
- Cada estímulo presenta ventajas y desafíos únicos para las aplicaciones MSN.
Conclusiones:
- Las MSN sensibles a estímulos son muy prometedoras para la administración de fármacos y la obtención de imágenes.
- Se necesita más investigación para superar los desafíos fundamentales para la traducción clínica.
- La optimización de los diseños de tapa y la comprensión de los mecanismos de estimulación son claves para el desarrollo futuro.
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