Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule02:17

Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule

15.2K
If a set of reactants can yield multiple constitutional isomers, but one of the isomers is obtained as the major product, the reaction is said to be regioselective. In such reactions, bond formation or breaking is favored at one reaction site over others.
The hydrohalogenation of an unsymmetrical alkene can yield two haloalkane products, depending on which vinylic carbon takes up the halogen. However, one product usually predominates, where hydrogen adds to the vinylic carbon bearing the...
15.2K
Regioselectivity and Stereochemistry of Hydroboration02:36

Regioselectivity and Stereochemistry of Hydroboration

8.7K
A significant aspect of hydroboration–oxidation is the regio- and stereochemical outcome of the reaction.
Hydroboration proceeds in a concerted fashion with the attack of borane on the π bond, giving a cyclic four-centered transition state. The –BH2 group is bonded to the less substituted carbon and –H to the more substituted carbon. The concerted nature requires the simultaneous addition of –H and –BH2 across the same face of the alkene giving syn stereochemistry.
8.7K
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry01:29

Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

5.0K
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
5.0K
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction01:16

[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

11.1K
The Diels–Alder reaction is an example of a thermal pericyclic reaction between a conjugated diene and an alkene or alkyne, commonly referred to as a dienophile. The reaction involves a concerted movement of six π electrons, four from the diene and two from the dienophile, forming an unsaturated six-membered ring. As a result, these reactions are classified as [4+2] cycloadditions.
11.1K
Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene01:17

Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene

6.7K
The electrophilic addition of hydrogen halides such as HBr to alkenes and nonconjugated dienes gives a single product as per Markovnikov’s rule.
6.7K
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration02:34

Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration

8.9K
The rate of acid-catalyzed hydration of alkenes depends on the alkene's structure, as the presence of alkyl substituents at the double bond can significantly influence the rate.
8.9K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Ligand-enabled distal desaturative lactonization of aliphatic acids.

Nature·2026
Same author

Fe(porphyrin)-Catalyzed Alkene Epoxidation with NaOCl: A Practical Small- and Large-Scale Alternative to <i>m</i>CPBA.

Journal of the American Chemical Society·2026
Same author

Ligand-Controlled Pd(II)-Catalyzed α,β-Unsaturation and β-Arylation of Long-Chain Acids.

Journal of the American Chemical Society·2026
Same author

Near-Infrared-Light-Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology.

Angewandte Chemie (International ed. in English)·2026
Same author

Ligand Design Enables Introduction of Nonaromatic Arylating Agents in Palladium-Catalyzed C-H Arylation of Arenes.

Journal of the American Chemical Society·2026
Same author

Engineering Isoquinoline-derived Directing Template for Distal C5-H Functionalization of Bicyclic Aza-arenes.

Angewandte Chemie (International ed. in English)·2025
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Nov 5, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.2K

Diversificación de las arenas a través de la funcionalización distal C2H

Uttam Dutta1, Sudip Maiti1, Trisha Bhattacharya1

  • 1Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Science (New York, N.Y.)
|May 14, 2021
PubMed
Resumen
Este resumen es generado por máquina.

Esta revisión cubre los avances en la activación distal de C-H catalizada por metales de transición. Destaca las estrategias para la funcionalización selectiva del sitio, superando los desafíos en la activación de enlaces meta y para-CH.

Más Videos Relacionados

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.0K
Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

11.8K

Videos de Experimentos Relacionados

Last Updated: Nov 5, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.2K
Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.0K
Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
09:35

Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units

Published on: September 18, 2016

11.8K

Área de la Ciencia:

  • Química orgánica
  • Catálisis
  • Metodología sintética

Sus antecedentes:

  • La activación de C-H catalizada por metales de transición ofrece rutas de síntesis eficientes.
  • La activación distal de C-H (meta / para) es un desafío debido a factores estéricos y electrónicos.
  • La funcionalización selectiva del sitio es clave para la síntesis de moléculas complejas.

Objetivo del estudio:

  • Revisar estrategias recientes para el control de la activación del arilo C-H distal.
  • Resaltar los métodos para superar los desafíos de la meta y parafuncionalización.
  • Mostrar los avances en el diseño de catalizadores y ligandos para la activación de C-H.

Principales métodos:

  • Revisión de la literatura sobre la dirección de las estrategias de grupo.
  • Análisis de los mediadores transitorios y directores sin rastro.
  • Examen de las interacciones no covalentes en la catálisis.
  • Evaluación de los efectos del catalizador y del ligando sobre la selectividad.

Principales resultados:

  • Demostración del éxito de la asistencia del grupo de dirección para la activación distal de C-H.
  • Exploración de nuevas estrategias de dirección transitorias y sin rastro.
  • Comprender el papel de las interacciones no covalentes en la regioselectividad.
  • Identificación de las características clave del catalizador y del ligando para la activación distal.

Conclusiones:

  • La activación distal de C-H se puede lograr a través de un catalisador sofisticado y un diseño de plantilla.
  • Existen múltiples estrategias para superar los desafíos inherentes a la meta y parafuncionalización.
  • Esta revisión proporciona información sobre el avance de la funcionalidad C-H selectiva del sitio.