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Updated: Nov 4, 2025

Dissection of Enhancer Function Using Multiplex CRISPR-based Enhancer Interference in Cell Lines
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La liberación de potenciadores y la reorientación activan los genes de susceptibilidad a enfermedades

Soohwan Oh1, Jiaofang Shao2, Joydeep Mitra3

  • 1Howard Hughes Medical Institute, Department and School of Medicine, University of California San Diego, La Jolla, CA, USA.

Nature
|May 27, 2021
PubMed
Resumen

Cuando se pierde un promotor genético preferido, los potenciadores pueden cambiar de objetivo, activando nuevos promotores. Este mecanismo de "liberación de potenciador y reorientación", influenciado por la unión de CTCF, puede activar genes de susceptibilidad a la enfermedad.

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