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Coordinan la regulación hormonal y sináptica del ARN mensajero de la vasopresina
F Baldino1, T M O'Kane, S Fitzpatrick-McElligott
1Medical Products Department, E. I. du Pont de Nemours & Company, Wilmington, DE 19898.
Science (New York, N.Y.)
|August 19, 1988
Resumen
Las lesiones unilaterales en el núcleo septal lateral aumentan la expresión de ARNm de arginina vasopresina (AVP) en el cerebro después de la adrenalectomía. Esto pone de relieve las influencias sinápticas en los niveles de ARNm AVP en las neuronas maduras del sistema nervioso central.
Área de la Ciencia:
- La neurociencia es la neurociencia.
- Biología Molecular Biología Molecular
- Endocrinología Endocrinología.
Sus antecedentes:
- La adrenalectomía aumenta el ARN mensajero de la arginina vasopresina (AVP) (ARNm) en el núcleo paraventricular adulto.
- Los mecanismos precisos de regulación de la expresión del ARNm AVP no se comprenden completamente.
Objetivo del estudio:
- Para investigar el efecto de las lesiones del núcleo septal lateral (LSN) en la expresión del ARNm AVP después de la adrenalectomía.
- Para explorar el papel de las influencias sinápticas en la modulación de los niveles de ARNm AVP.
Principales métodos:
- Se crearon lesiones unilaterales en el núcleo septal lateral de ratas adultas.
- Se realizó una adrenalectomía.
- La hibridación in situ se utilizó para cuantificar los niveles de ARNm AVP en núcleos cerebrales específicos, en particular el núcleo paraventricular (PVN).
- Se empleó inmunohistoquímica para examinar la colocalización de AVP y oxitocina.
Principales resultados:
- Las lesiones unilaterales de LSN aumentaron significativamente el aumento inducido por adrenalectomía en los niveles de ARNm AVP.
- Esta mejora se observó ipsilateralmente al sitio de la lesión.
- El efecto fue más pronunciado en el núcleo paraventricular rostral y los núcleos asociados.
- Un subconjunto de neuronas mostró colocalización de AVP y oxitocina, junto con sus respectivos ARNm.
Conclusiones:
- Las influencias sinápticas, originadas en el núcleo septal lateral, modulan la expresión de ARNm de la arginina vasopresina.
- Estos hallazgos sugieren que el sistema nervioso central selecciona dinámicamente los fenotipos neuronales a través de mecanismos mediados sinápticamente en cerebros maduros.
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