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Updated: Nov 3, 2025

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
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El acoplamiento canónico del receptor de células T al péptido-MHC es esencial para la señalización de las células T

Pirooz Zareie1, Christopher Szeto1, Carine Farenc1

  • 1Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

Science (New York, N.Y.)
|June 4, 2021
PubMed
Resumen

La polaridad de acoplamiento del receptor de células T (TCR) es esencial para la activación de las células T, no solo para el reconocimiento. El acoplamiento inverso de TCR evita la señalización de las células T al deslocalizar proteínas clave como Lck, destacando las restricciones de señalización.

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