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Olfaction01:25

Olfaction

46.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
46.4K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

10.3K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
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Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
10.0K
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

5.4K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
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Association Areas of the Cortex01:21

Association Areas of the Cortex

7.3K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
7.3K
Somatosensation01:33

Somatosensation

41.3K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
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Video Experimental Relacionado

Updated: Nov 2, 2025

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation
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La deriva de representación en la corteza olfativa primaria

Carl E Schoonover1, Sarah N Ohashi2,3, Richard Axel4

  • 1Howard Hughes Medical Institute, Mortimer B. Zuckerman Mind Brain Behavior Institute, Department of Neuroscience, Columbia University, New York, NY, USA. ces2001@columbia.edu.

Nature
|June 10, 2021
PubMed
Resumen
Este resumen es generado por máquina.

Las respuestas de la corteza olfativa a los olores son inestables, variando significativamente durante semanas. Esta inestabilidad en la corteza piriforme desafía su papel en la percepción estable del olor y puede ser común en otras regiones del cerebro.

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Área de la Ciencia:

  • La neurociencia
  • Investigación del sistema olfativo
  • Percepción sensorial

Sus antecedentes:

  • La constancia perceptiva se basa en representaciones cerebrales estables de la entrada sensorial.
  • Se cree que la corteza piriforme (corteza olfativa) codifica la identidad del olor.

Objetivo del estudio:

  • Investigar la estabilidad de las respuestas neurales evocadas por el olor en la corteza piriforme del ratón durante períodos prolongados.
  • Para determinar si el condicionamiento del miedo o la exposición repetida al olor puede estabilizar estas respuestas.

Principales métodos:

  • Registros electrofisiológicos de unidades individuales en la corteza piriforme del ratón durante varias semanas.
  • Utilización de un clasificador lineal para evaluar el rendimiento de la discriminación de olores a lo largo del tiempo.
  • Implementar el condicionamiento del miedo y los paradigmas de exposición diaria al olor.

Principales resultados:

  • Las respuestas evocadas por el olor en la corteza piriforme exhibieron una deriva significativa durante días o semanas.
  • Un clasificador entrenado en respuestas iniciales perdió precisión, acercándose a los niveles de probabilidad después de 32 días.
  • Ni el condicionamiento del miedo ni la exposición diaria al olor impidieron la deriva de la respuesta.

Conclusiones:

  • La corteza piriforme muestra una deriva continua en las respuestas evocadas por el olor, cuestionando su papel en la percepción estable del olor.
  • Esta inestabilidad neuronal puede ser una característica de la conectividad no estructurada de la corteza piriforme.
  • Tal inestabilidad podría ser una propiedad compartida por otras áreas corticales no estructuradas.