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Cell Migration01:19

Cell Migration

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

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In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
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Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

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The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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Adherens Junctions01:24

Adherens Junctions

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Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
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Updated: Nov 2, 2025

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
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Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

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Morfogénesis epitelial en ciernes impulsada por la matriz celular frente a la adhesión celular

Shaohe Wang1, Kazue Matsumoto1, Samantha R Lish2

  • 1Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Cell
|June 16, 2021
PubMed
Resumen
Este resumen es generado por máquina.

El brote epitelial estratificado, crucial para el desarrollo de órganos, es impulsado por propiedades específicas de adhesión celular. Una matriz celular fuerte y una adhesión celular débil en las células periféricas permiten este paso clave.

Palabras clave:
E-cadarina y sus derivadosMorfogénesis ramificadaMorfogénesis en broteAdhesión entre célulasAdhesión de la matriz celularAdhesión diferencialMorfogénesis epitelialLa integrinaGlándulas salivalesingeniería de tejidos

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Área de la Ciencia:

  • Biología del desarrollo
  • Biología celular
  • La biofísica

Sus antecedentes:

  • La morfogénesis epitelial es esencial para la formación de órganos complejos como la glándula salival y el páncreas.
  • Los mecanismos que impulsan el brote y la ramificación en el epitelio estratificado no se comprenden completamente.

Objetivo del estudio:

  • Elucidar los impulsores celulares y moleculares del brote epitelial estratificado durante el desarrollo de órganos embrionarios.
  • Investigar el papel de la adhesión celular en el inicio de la morfogénesis ramificada.

Principales métodos:

  • Imágenes de órganos vivos de las glándulas salivales embrionarias de ratón con resolución de una sola célula.
  • Perfiles de transcriptoma de una sola célula para identificar patrones de expresión génica espaciales.
  • Culturas esferoides 3D con manipulación experimental de las moléculas de adhesión celular (E-cadherina) y inducción de la membrana basal.

Principales resultados:

  • La morfogénesis en brote es impulsada por células epiteliales de superficie con una fuerte matriz celular y adherencias débiles entre células.
  • Los patrones de transcripción espacial se correlacionan con las diferencias observadas en la adhesión celular.
  • La reconstitución sintética confirmó que la E-cadherina suprimida y la membrana basal inducida, con señalización de la β1-integrina, permiten el brote.

Conclusiones:

  • El brote epitelial estratificado es iniciado por una hoja celular distinta con propiedades de adhesión diferenciales.
  • La fuerte adhesión célula-matriz y la débil adhesión célula-célula son críticas para el paso inicial de brote en la morfogénesis de ramificación.
  • Este estudio proporciona una comprensión mecanicista del brote epitelial, esencial para la formación de órganos.