Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Inflammatory Response01:28

Inflammatory Response

13.8K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
13.8K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

13.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.5K
Inflammation01:38

Inflammation

56.9K
Overview
56.9K
Adherens Junctions01:24

Adherens Junctions

5.4K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
5.4K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

6.3K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
6.3K
Surface Membrane Barriers01:18

Surface Membrane Barriers

1.8K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.8K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Aneuploidy selects for the acquisition of driver genes in breast cancer.

Nature·2026
Same author

Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.

Immunity·2026
Same author

<i>SPP1</i><sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Science translational medicine·2026
Same author

ArchVelo: archetypal velocity modeling for single-cell multi-omic trajectories.

Nature communications·2026
Same author

Upadacitinib Achieved Rapid Response in Biologic-Refractory Immune Checkpoint Inhibitor-Related Enterocolitis.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2026
Same author

Metadomain and metaloop genome interactions in mammalian T cells.

Cell reports·2026

Video Experimental Relacionado

Updated: Nov 1, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.5K

Adaptación inflamatoria en los tejidos de barrera

Rachel E Niec1, Alexander Y Rudensky2, Elaine Fuchs3

  • 1Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA; Department of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.

Cell
|June 25, 2021
PubMed
Resumen

Los tejidos de la barrera epitelial recuerdan la inflamación, mejorando las respuestas futuras. Sin embargo, esta memoria inmune puede empeorar la enfermedad alimentando la inflamación crónica.

Más Videos Relacionados

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Investigating Intestinal Barrier Breakdown in Living Organoids
07:18

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

13.6K

Videos de Experimentos Relacionados

Last Updated: Nov 1, 2025

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

12.5K
Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
06:31

Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids

Published on: June 2, 2023

1.2K
Investigating Intestinal Barrier Breakdown in Living Organoids
07:18

Investigating Intestinal Barrier Breakdown in Living Organoids

Published on: March 26, 2020

13.6K

Área de la Ciencia:

  • Inmunología
  • Reparación de tejidos
  • Comunicaciones celulares

Sus antecedentes:

  • El epitelio superficial forma una barrera crucial contra las amenazas externas.
  • Las células epiteliales y inmunes colaboran para controlar las infecciones y reparar el daño después de las violaciones de la barrera.
  • Los eventos inflamatorios pueden conducir a alteraciones duraderas del tejido, influyendo en las respuestas inmunes posteriores.

Objetivo del estudio:

  • Para revisar las redes de comunicación celular en los tejidos de barrera.
  • Explorar la integración de las células inmunes residentes y reclutadas con las células madre del tejido.
  • Comprender los mecanismos subyacentes a la adaptación de los tejidos al estrés ambiental y a la inflamación.

Principales métodos:

  • Revisión de la literatura sobre la comunicación celular en los tejidos de la barrera.
  • Análisis de las interacciones de las células inmunes y las funciones de las células madre de los tejidos.
  • Examen de la memoria inflamatoria y su impacto en la adaptación tisular.

Principales resultados:

  • Las experiencias inflamatorias crean la memoria del tejido, mejorando las respuestas protectoras futuras.
  • La memoria inflamatoria disfuncional puede exacerbar los estados de enfermedad.
  • Las complejas redes celulares que involucran células epiteliales, inmunes y madre impulsan la adaptación del tejido.

Conclusiones:

  • La memoria tisular es un arma de doble filo, crucial para la defensa pero potencialmente dañina en la enfermedad.
  • Comprender estas redes celulares es clave para controlar las enfermedades inflamatorias.
  • Dirigirse a estas vías de comunicación puede ofrecer estrategias terapéuticas para la reparación de tejidos y el control de enfermedades.