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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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Montaje de estructuras orgánicas metálicas basadas en clústeres quirales y el efecto de memoria de quiralidad durante
Guocheng Deng1, Boon K Teo1, Nanfeng Zheng1
1Collaborative Innovation Center of Chemistry for Energy Materials, State Key Laboratory for Physical Chemistry of Solid Surfaces, National & Local Joint Engineering Research Center of Preparation Technology of Nanomaterials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Journal of the American Chemical Society
|June 28, 2021
Resumen
Este estudio introduce una estrategia de ensamblaje-desensamblaje para separar los racimos metálicos en enantiómeros ópticamente puros. Este método utiliza enlaces quirales para crear marcos homoquirales metálico-orgánicos, lo que permite el aislamiento de grupos de plata quirales puros.
Área de la Ciencia:
- Ciencias de los materiales
- Química supramolecular
- Nanotecnología
Sus antecedentes:
- Muchos grupos de metales son quirales pero son difíciles de sintetizar en formas enantioméricamente puras.
- Las mezclas racemicas de grupos metálicos quirales a menudo limitan sus aplicaciones en tecnologías quirales.
Objetivo del estudio:
- Desarrollar una estrategia eficiente para la obtención de grupos metálicos quirales ópticamente puros a partir de mezclas racémicas.
- Demostrar la utilidad de un enfoque de ensamblaje-desensamblaje utilizando enlaces quirales y grupos metálicos.
Principales métodos:
- Síntesis de grupos quirales de Ag14 y su ensamblaje en estructuras metal-orgánicas (MOF) utilizando enlaces quirales bidentados (LR y LS).
- Caracterización de las MOF resultantes (Ag-LR, Ag-LS, Ag-LRS) mediante el uso de la cristalografía de rayos X.
- Desmontaje de los MOF mediante hidrólisis para recuperar los racimos de R-Ag14 y S-Ag14 ópticamente puros.
Principales resultados:
- Se obtuvieron con éxito racimos homoquirales de R-Ag14 y S-Ag14 dentro de MOFs quirales (Ag-LR y Ag-LS).
- El MOF achiral (Ag-LRS) se cristalizó con una estructura similar al diamante que contiene grupos de R-Ag14 y S-Ag14.
- Se aislaron enantiómeros R-Ag14 y S-Ag14 ópticamente puros después del desmontaje de los MOFs quirales.
Conclusiones:
- La estrategia de ensamblaje-desensamblaje separa efectivamente los racimos metálicos en sus enantiómeros constituyentes.
- Este método proporciona una vía viable para producir moléculas de racimo quirales ópticamente puras para aplicaciones avanzadas.
- La estrategia desarrollada puede aplicarse a la construcción de materiales quirales basados en clúster.
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