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NNT media la pigmentación redox-dependiente a través de un mecanismo independiente de UVB y MITF
Jennifer Allouche1, Inbal Rachmin1, Kaustubh Adhikari2
1Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Cell
|July 7, 2021
Resumen
Se ha descubierto un nuevo mecanismo para la pigmentación de la piel independiente de la luz UV y MITF. Dirigirse a la enzima nicotinamida nucleótido transhidrogenasa (NNT) influye en el oscurecimiento de la piel y la producción de melanina.
Área de la Ciencia:
- La genética
- La bioquímica
- Dermatología
Sus antecedentes:
- El color de la piel está determinado por la luz UV y los factores genéticos.
- No se comprende completamente la vía de pigmentación de la piel independiente del MITF.
Objetivo del estudio:
- Para aclarar un nuevo mecanismo de pigmentación de la piel.
- Para investigar el papel de la nicotinamida nucleótido transhidrogenasa (NNT) en la pigmentación de la piel.
- Explorar el NNT como objetivo terapéutico para los trastornos de la pigmentación de la piel.
Principales métodos:
- Se dirige a la enzima NNT para inducir cambios redox celulares.
- Evaluación de la maduración de los melanosomas y los niveles de eumelanina.
- Aplicación tópica de inhibidores de NNT de molécula pequeña en la piel humana.
- Análisis de la función NNT en ratones y peces cebra.
- Análisis genómico de cohortes humanas para los polimorfismos de NNT.
Principales resultados:
- La orientación de NNT altera el redox celular, afectando la degradación de la tirosinasa y la maduración del melanosoma.
- La inhibición de NNT conduce al oscurecimiento de la piel en humanos y al aumento de la pigmentación en ratones.
- La modificación genética de NNT impacta la pigmentación melanocítica en el pez cebra.
- Los polimorfismos de un solo nucleótido de NNT están asociados con el color de la piel humana, el bronceado y los comportamientos de protección solar.
- La disminución de los niveles de NNT en la piel se correlaciona con la hiperpigmentación posinflamatoria y las lentigines.
Conclusiones:
- Se ha identificado un nuevo mecanismo de pigmentación de la piel, independiente de los rayos UV y MITF, regulado por NNT.
- El NNT juega un papel crucial en el control de la producción de eumelanina a través de vías dependientes de redox.
- La orientación de NNT con medicamentos tópicos ofrece potencial para aplicaciones médicas y cosméticas en el manejo de la pigmentación de la piel.
Palabras clave:
El MITFEl UVBEl melanosomaTranshidrogenasa del nucleótido de nicotinamidapigmentaciónRegulación de oxidación y oxidaciónMás Videos Relacionados
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