Video Experimental Relacionado

Updated: Oct 29, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.1K

Explorando el proceso de activación del complejo β2AR-G

Chen Bai1,2, Junlin Wang2, Dibyendu Mondal1

  • 1Department of Chemistry, University of Southern California, Los Angeles, California 90089-1062, United States.

Journal of the American Chemical Society
|July 13, 2021
PubMed
Resumen

Los receptores acoplados a proteínas G (GPCR) son vitales para la señalización celular y el desarrollo de fármacos. Este estudio revela que la liberación de difosfato de guanosina (GDP) de la proteína Gs ocurre cuando la cavidad de unión está medio abierta, un paso clave en la activación de la GPCR.

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