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Análisis observacional internacional de la evolución y los resultados de la angina crónica estable: el estudio
Jules Mesnier1,2, Gregory Ducrocq1,2,3,4, Nicolas Danchin4,5
1Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, France (J.M., G.D., P.G.S.).
Circulation
|July 15, 2021
Resumen
Los pacientes con enfermedad coronaria estable con angina a menudo ven la resolución de los síntomas con un tratamiento conservador. Este enfoque predice resultados similares a nunca tener angina, destacando su valor.
Área de la Ciencia:
- Cardiología
- Medicina Clínica
- Epidemiología
Sus antecedentes:
- La angina es común en pacientes con enfermedad coronaria estable.
- Existen datos limitados sobre la prevalencia, la evolución y los resultados de la angina con los tratamientos modernos.
Objetivo del estudio:
- Para investigar la historia natural de la angina en el CAD estable.
- Para analizar el impacto del estado de angina en los resultados cardiovasculares a largo plazo.
Principales métodos:
- Análisis de 32.691 pacientes del registro de CLARIFY.
- Evaluación anual del estado anginal en pacientes sin nueva revascularización o infarto de miocardio.
- Análisis multivariable de los cambios en la angina de 1 año en los resultados de 5 años.
Principales resultados:
- La angina se resolvió en un año en el 39,6% de los pacientes sin revascularización.
- La resolución a menudo se logró sin cambios en la medicación (84,4%).
- Los riesgos aumentados de muerte cardiovascular o infarto de miocardio por angina persistente o nueva (HRs ajustados 1.32 y 1.37).
Conclusiones:
- La mayoría de los pacientes estables con CAD con angina experimentan la resolución de los síntomas.
- El tratamiento conservador que conduce a la resolución de la angina está asociado con resultados favorables.
- Hace hincapié en el valor del manejo conservador sobre la revascularización de rutina para la angina estable.
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