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Mejora tónica de la señalización STING mediada por la enfermedad de Niemann-Pick tipo C

Ting-Ting Chu1, Xintao Tu1, Kun Yang1

  • 1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature
|July 22, 2021
PubMed
Resumen

Este estudio revela una nueva forma de activación del STING (estimulador de genes de interferón), independiente del cGAS. La proteína Niemann-Pick tipo C1 (NPC1) vincula el STING con el tráfico celular, lo que afecta a la enfermedad neurológica.

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