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Selección dinámica constitucional a bajo número de Reynolds en un sistema dinámico triple: adaptación dinámica

Ruirui Gu^1,2, Jean-Marie Lehn^1,2

¹Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.

Journal of the American Chemical Society

|August 25, 2021

Resumen

Los investigadores diseñaron un sistema complejo dinámico triple utilizando química covalente dinámica y autoensamblaje supramolecular. Este sistema demuestra una adaptación impulsada por la autoorganización y una composición sintonizable, imitando a los sistemas vivos.

Área de la Ciencia:

Química supramolecular
Química Covalente Dinámica
Ciencias de los materiales

Sus antecedentes:

La química covalente dinámica (DCC) y el autoensamblaje supramolecular son clave para crear materiales adaptativos.
Los sistemas complejos requieren un control preciso sobre las interacciones y la organización de los componentes.

Objetivo del estudio:

Diseñar e investigar un sistema complejo dinámico triple que integre el DCC y el autoensamblaje supramolecular.
Explorar la adaptación constitucional impulsada por la autoorganización y la composición sintonizable del sistema.

Principales métodos:

Se establecieron dos bibliotecas covalentes dinámicas (DCL-1 y DCL-2) basadas en la organo-metatesis CC/CN.
Utilizó los constituyentes de Knoevenagel a base de ácido barbitúrico para la autoorganización secuencial en polímeros supramoleculares (SP) y geles.
Efectos investigados de la temperatura y el disolvente en los patrones de distribución de DCL-2.

Principales resultados:

El sistema demostró una amplificación selectiva impulsada por la autoorganización que condujo a la formación de SP.
El calentamiento causó la disociación reversible y la aleatorización de los constituyentes de SP.
La composición sintonizable se logró a través de la selección de componentes covalentes dinámicos acoplados y la organización supramolecular en dos etapas.

Conclusiones:

El sistema complejo triple dinámico diseñado exhibe una notable adaptación constitucional impulsada por la autoorganización.
La composición sintonizable del sistema destaca la interacción entre la química covalente dinámica y la organización supramolecular.
Estos hallazgos ofrecen información sobre los mecanismos dinámicos de adaptación relevantes para las condiciones de bajo número de Reynolds en los sistemas vivos.

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