Video Experimental Relacionado
Updated: Oct 21, 2025
09:26
Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro
Published on: June 6, 2025
743
Los orígenes del SARS-CoV-2: una revisión crítica
Edward C Holmes1, Stephen A Goldstein2, Angela L Rasmussen3
1Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
Cell
|September 4, 2021
Resumen
El origen del coronavirus 2 del síndrome respiratorio agudo severo (SARS-CoV-2) se debate entre un escape de laboratorio y la aparición de una zoonosis. Esta revisión examina críticamente la evidencia científica para aclarar el surgimiento del SARS-CoV-2.
Área de la Ciencia:
- Virología
- Epidemiología
- Salud pública
Sus antecedentes:
- El surgimiento del síndrome respiratorio agudo severo coronavirus 2 (SARS-CoV-2) a finales de 2019 provocó una investigación científica global.
- Las hipótesis clave con respecto al origen del SARS-CoV-2 incluyen contagio zoonótico y eventos asociados con el laboratorio.
Objetivo del estudio:
- Revisar críticamente y sintetizar la evidencia científica actual relacionada con el origen del SARS-CoV-2.
- Evaluar la plausibilidad de las hipótesis que compiten para la aparición del SARS-CoV-2.
Principales métodos:
- Revisión exhaustiva de la literatura de estudios virológicos, epidemiológicos y ecológicos.
- Análisis crítico de la evidencia que apoya o refuta los orígenes zoonóticos y de laboratorio.
Principales resultados:
- La síntesis de la evidencia indica una compleja interacción de factores que influyen en el origen.
- Análisis presentado para apoyar o desafiar aspectos específicos de cada hipótesis.
Conclusiones:
- El origen del SARS-CoV-2 requiere una investigación científica más rigurosa.
- Comprender el camino de emergencia es crucial para prevenir futuras pandemias.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:05Single Nucleotide Polymorphisms-SNPs
16.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
16.9K
02:33Retroviruses
13.1K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
13.1K
02:50Conjugated Proteins
21.4K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
21.4K
01:03Rous Sarcoma Virus (RSV) and Cancer
5.6K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.6K
00:36Viral Mutations
35.4K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
35.4K
02:28Leaky Scanning
5.3K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.3K