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Generación y transmisión de recombinantes interlineales en la pandemia de SARS-CoV-2
Ben Jackson1, Maciej F Boni2, Matthew J Bull3
1Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.
Cell
|September 9, 2021
Resumen
Múltiples recombinaciones de SARS-CoV-2 surgieron de forma independiente en el Reino Unido. Estos virus combinaron rasgos genéticos de la variante B.1.1.7 con otras cepas circulantes, mostrando evidencia de transmisión.
Área de la Ciencia:
- Virología
- La genómica
- Epidemiología
Sus antecedentes:
- El surgimiento de las variantes del SARS-CoV-2, como B.1.1.7, ha impactado significativamente en la pandemia de COVID-19.
- Los eventos de recombinación en los virus de ARN pueden conducir a nuevos linajes con características alteradas.
Objetivo del estudio:
- Investigar los orígenes y características de los virus recombinantes del SARS-CoV-2 detectados en el Reino Unido.
- Para determinar la composición genética y los patrones de transmisión de estas nuevas cepas recombinantes.
Principales métodos:
- Análisis filogenético de los genomas del SARS-CoV-2 muestreados en el Reino Unido.
- Identificación de los puntos de ruptura de recombinación y caracterización de los linajes parentales.
- Seguimiento de los grupos de transmisión y la propagación de los virus recombinantes.
Principales resultados:
- Evidencia de múltiples orígenes independientes de virus recombinantes del SARS-CoV-2 en el Reino Unido entre finales de 2020 y principios de 2021.
- Los genomas recombinantes contenían mutaciones características de B.1.1.7 junto con material genético de virus no B.1.1.7 en co-circulación.
- Se identificaron cuatro casos de transmisión posterior, incluido un grupo de 45 casos.
- Los puntos de ruptura de recombinación ubicaron consistentemente la región del pico de B.1.1.7, lo que sugiere una posible ventaja de transmisión.
Conclusiones:
- Los hallazgos indican que la recombinación del SARS-CoV-2 es un proceso evolutivo en curso en el Reino Unido.
- La herencia consistente de la región del pico B.1.1.7 en los recombinantes sugiere la selección de mutaciones ventajosas.
- Comprender la dinámica de recombinación es crucial para monitorear la evolución viral y predecir las trayectorias de futuras pandemias.
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