Video Experimental Relacionado
Updated: Oct 20, 2025
09:04
Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
825
Los roles opuestos del sistema inmunológico en los tumores
Won Jin Ho1, Laura D Wood1,2
1Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Science (New York, N.Y.)
|September 16, 2021
Resumen
La inflamación impulsa el desarrollo temprano del cáncer, pero debe superarse para que los tumores avancen. Comprender esta dinámica es clave para las nuevas terapias contra el cáncer.
Área de la Ciencia:
- En el campo de la oncología
- Inmunología
- Biología molecular
Sus antecedentes:
- La inflamación es un factor conocido de la tumorigénesis temprana.
- La progresión del tumor requiere evasión de la respuesta inflamatoria.
Objetivo del estudio:
- Para investigar el doble papel de la inflamación en el cáncer.
- Para entender cómo los tumores evitan la inflamación durante la progresión.
Principales métodos:
- Revisión de la literatura existente sobre inflamación y cáncer.
- Análisis de los mecanismos moleculares subyacentes a la tumorigénesis inducida por la inflamación.
- Examen de las estrategias de evasión del tumor.
Principales resultados:
- La inflamación promueve inicialmente la iniciación y el crecimiento del tumor.
- Los tumores establecidos desarrollan mecanismos para suprimir o evadir las señales inflamatorias.
- Esta evasión es crítica para la progresión y metástasis sostenidas del tumor.
Conclusiones:
- El papel de la inflamación en el cáncer es dependiente del contexto, cambiando de promoción a un objetivo para la evasión.
- Dirigirse a los mecanismos de evasión de la inflamación puede ofrecer nuevas estrategias terapéuticas para los cánceres avanzados.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:27Tumor Immunotherapy
743
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
743
02:17The Tumor Microenvironment
7.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.0K
01:27Cytotoxic T Cells-mediated Immune Response
4.8K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
4.8K
01:40Cell-mediated Immune Responses
76.0K
Overview
76.0K
01:29Immune Response Against Viral Pathogens
1.1K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.1K
01:28Functions of the Lymphatic and Immune System
4.8K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
4.8K