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Mapeo de la evolución genómica y epigenómica en los ecosistemas de cáncer
Toshikazu Ushijima1, Susan J Clark2,3, Patrick Tan4,5,6,7
1Division of Epigenomics, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Science (New York, N.Y.)
|September 23, 2021
Resumen
La integración de datos multimodales es crucial para comprender el cáncer
Área de la Ciencia:
- En el campo de la oncología
- La genómica
- La epigenómica
Sus antecedentes:
- El cáncer, una de las principales causas de muerte, surge de cambios genómicos y epigenómicos.
- Las alteraciones moleculares tempranas en tejidos aparentemente normales desafían las definiciones tradicionales de iniciación del cáncer.
- Las etapas posteriores incluyen selección clonal, adaptación epigenómica y células persistentes en metástasis y resistencia al tratamiento.
Objetivo del estudio:
- Hacer hincapié en la importancia de la integración multimodal de datos en la investigación del cáncer.
- Explorar la evolución molecular del cáncer a lo largo de todo su ciclo de vida.
- Destacar las áreas de investigación emergentes en el desarrollo y tratamiento del cáncer.
Principales métodos:
- Integración de los datos multimodales
- Análisis de las alteraciones genómicas y epigenómicas.
- Aplicación de tecnologías unicelulares y espaciales.
Principales resultados:
- Las mutaciones conductoras y las alteraciones epigenéticas están presentes en los tejidos normales.
- La selección clonal, la adaptación epigenómica y las células persistentes influyen en la metástasis y la resistencia al tratamiento.
- Los ecosistemas tumorales juegan un papel clave en el desarrollo del cáncer, revelado por las tecnologías avanzadas.
Conclusiones:
- La integración multimodal de datos es esencial para comprender la evolución molecular del cáncer.
- El desarrollo de atlas tumorales completos a lo largo del ciclo de vida del cáncer es vital.
- Este enfoque mejorará la evaluación del riesgo de cáncer y acelerará el descubrimiento terapéutico.
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