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La autofagia circadiana impulsa la longevidad mediada por el iTRF
Matt Ulgherait1, Adil M Midoun2, Scarlet J Park3,4
1Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Nature
|September 30, 2021
Resumen
La alimentación intermitente con restricción de tiempo (iTRF) extiende la vida útil y retrasa los marcadores de envejecimiento en las moscas de la fruta al mejorar la autofagia regulada circadiana. Esto sugiere beneficios potenciales para la salud humana a través de intervenciones similares.
Área de la Ciencia:
- Gerontología
- Cronología
- Biología molecular
Sus antecedentes:
- La alimentación con restricción de tiempo (TRF) es una estrategia dietética que restringe la ingesta de alimentos a horas diarias específicas, mostrando potencial como una intervención antienvejecimiento.
- Los mecanismos moleculares que subyacen a los beneficios para la salud del TRF, particularmente su vínculo con los ritmos circadianos, siguen siendo en gran medida inexplorados.
Objetivo del estudio:
- Investigar los efectos de la alimentación intermitente por tiempo restringido (iTRF) en la esperanza de vida y los marcadores de envejecimiento en Drosophila.
- Aclarar las vías moleculares, específicamente la regulación circadiana y la autofagia, involucradas en los beneficios para la salud mediados por iTRF.
Principales métodos:
- Desarrolló e implementó un régimen de alimentación intermitente con restricción de tiempo (iTRF) en Drosophila.
- Se evaluó la extensión de la vida útil y la aparición de marcadores de envejecimiento en los músculos y el intestino.
- Se analizó el papel de la regulación circadiana y la autofagia en la mediación de los efectos de iTRF, incluido el momento específico de la inducción de la autofagia.
Principales resultados:
- iTRF extendió significativamente la vida útil de las moscas y retrasó los marcadores de envejecimiento.
- iTRF mejoró la transcripción genética regulada por el ritmo circadiano.
- La prolongación de la vida útil por iTRF dependía tanto de la regulación circadiana como de la autofagia.
- La inducción de la autofagia nocturna fue necesaria y suficiente para prolongar la vida, mientras que la inducción diurna no lo fue.
Conclusiones:
- La autofagia regulada por el ciclo circadiano es un mecanismo crítico que subyace a los beneficios para la salud de iTRF en Drosophila.
- Estos hallazgos sugieren que las intervenciones dirigidas a la autofagia regulada circadiana podrían ofrecer beneficios antienvejecimiento y prolongar la vida útil en humanos.
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