Video Experimental Relacionado
Updated: Oct 17, 2025
08:59
Author Spotlight: Advancements in Multichannel Extracellular Recording for Studying Neuronal Activity in Freely Moving Mice
Published on: May 26, 2023
3.1K
Anatomía celular de la corteza motora primaria del ratón
Rodrigo Muñoz-Castañeda1, Brian Zingg2,3, Katherine S Matho1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Nature
|October 7, 2021
Resumen
Los investigadores crearon un mapa 3D detallado del área de las extremidades superiores de la corteza motora primaria del ratón (MOp-ul). Este marco anatómico integra tipos de células y diagramas de cableado para avanzar en la comprensión de la función cerebral.
Área de la Ciencia:
- La neurociencia
- La neuroanatomía
- Neurociencia de los sistemas
Sus antecedentes:
- La comprensión de la función cerebral requiere un marco estructural de resolución celular para integrar conjuntos de datos a múltiples escalas.
- La Red de Censos Celulares de la Iniciativa Cerebral (BICCN) tiene como objetivo crear atlas celulares completos del cerebro.
Objetivo del estudio:
- Para obtener una descripción anatómica basada en el tipo de célula de la corteza motora primaria del ratón, área de las extremidades superiores (MOp-ul).
- Establecer un marco estructural 3D con resolución celular para el MOp-ul.
- Facilitar la integración e interpretación de datos cerebrales a varias escalas.
Principales métodos:
- Utilizó técnicas de etiquetado genético y viral.
- Anatomía codificada empleada resuelta por secuenciación.
- Realizamos la reconstrucción de una sola neurona y tomamos imágenes de todo el cerebro.
- Aprovechó herramientas de neuroinformática basadas en la nube para el análisis de datos.
Principales resultados:
- Con éxito delineado el MOp-ul en 3D.
- Se ha perfeccionado la organización sublaminar del MOp-ul.
- Se definieron aproximadamente dos docenas de tipos de neuronas de proyección dentro de la MOp-ul.
- Generó un diagrama de cableado de entrada y salida para el MOp-ul.
Conclusiones:
- Este estudio proporciona una descripción anatómica detallada de la resolución celular de la MOp-ul.
- El marco desarrollado y el diagrama de cableado ayudarán a futuros análisis de los circuitos de control del motor.
- Este trabajo ofrece una hoja de ruta para descripciones integrales de resolución celular de la arquitectura del cerebro de los mamíferos.
Videos de Conceptos Relacionados
01:14Motor and Sensory Areas of the Cortex
5.1K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
5.1K
01:24Somatosensory, Motor, and Association Cortex
1.2K
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
1.2K
01:33Somatosensation
40.6K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
40.6K
01:11Direct Motor Pathways
2.8K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.8K