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Las sinapsis mecanorreceptoras en el tronco cerebral dan forma a la representación central del tacto
Brendan P Lehnert1, Celine Santiago1, Erica L Huey1
1Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA; Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Cell
|October 12, 2021
Resumen
La región de la piel innervada por los receptores del tacto influye en cómo se desarrollan sus conexiones cerebrales. Las representaciones brillantes del tacto de la piel se expanden centralmente durante el desarrollo, incluso sin sentir un toque suave.
Área de la Ciencia:
- La neurociencia
- Biología del desarrollo
- Sistemas sensoriales
Sus antecedentes:
- Los mamíferos utilizan la piel glabra (sin pelo) en las manos y los pies para la interacción ambiental.
- Los mapas corticales muestran representaciones agrandadas de la sensación de piel glabra, vinculadas a una alta densidad de mecanorreceptores.
Objetivo del estudio:
- Para investigar cómo se desarrolla la representación desproporcionada de la piel glabra en el tronco cerebral.
- Determinar el papel de los mecanorreceptores periféricos y sus sinapsis centrales en la configuración de la percepción táctil.
Principales métodos:
- Estudió el desarrollo postnatal de las sinapsis mecanorreceptoras en el tronco cerebral.
- Examinado el refinamiento sináptico basado en la proximidad a la piel glabra.
- Se utilizaron ratones con sensibilidad al tacto disminuida.
Principales resultados:
- La representación desproporcionada de la piel glabra surge durante el desarrollo posnatal en la primera sinapsis central.
- Las sinapsis mecanorreceptoras que innervan la piel glabra se refinan, expandiendo su representación central.
- Los mecanorreceptores de la piel brillante forman sinapsis cerebrales más fuertes incluso en ratones que carecen de sensación de tacto suave.
Conclusiones:
- La región de la piel innervada por mecanorreceptores guía el refinamiento del desarrollo de sus sinapsis centrales.
- Este proceso da forma a la representación del tacto en el cerebro, destacando la importancia de la entrada periférica en la formación del mapa neural.
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