Video Experimental Relacionado

Updated: Oct 17, 2025

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
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Un retrotransposón específico de ratón impulsa una isoforma Cdk2ap1 conservada esencial para el desarrollo

Andrew J Modzelewski1, Wanqing Shao2, Jingqi Chen1

  • 1Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|October 13, 2021
PubMed
Resumen

Los elementos transponibles, específicamente los promotores de retrotransposón de repetición terminal larga, impulsan la regulación génica durante el desarrollo temprano de los mamíferos. Los promotores de transposones específicos de la especie generan isoformas de proteínas conservadas con nuevas funciones, lo que afecta a la divergencia del desarrollo.

Palabras clave:
Cdk2 y Cdk2Cdk2ap1 y Cdk2ap2Proliferación de las célulasla implantaciónLos mamíferosel ratónEmbriones de preimplantaciónLos promotoresLos retrotransposonesLos transposones

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