Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

5.8K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.8K
Positive Regulator Molecules02:39

Positive Regulator Molecules

5.8K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.8K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.1K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.1K
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

5.0K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
5.0K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.1K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

C3 in <i>Pomacea canaliculata</i>: a conserved effector with developmental and immune roles.

Frontiers in cellular and infection microbiology·2026
Same author

Correction: RAPID-LC: rapid evidence-to-practice uptake of large core thrombectomy across a stroke consortium.

Journal of neurology·2026
Same author

Mapping the dialogue: Decoding alveolar stem-niche interactions.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Brain and physiological responses to flavored waters with different sweeteners: a randomized crossover study in healthy young adults.

The American journal of clinical nutrition·2026
Same author

Cancer of unknown primary genomic profiling from cell-free DNA provides insights into CUP biology and vulnerabilities.

Frontiers in medicine·2026
Same author

Association between EAT-Lancet diet adherence and cancer incidence/mortality: a systematic review and meta-analysis.

Frontiers in oncology·2026

Video Experimental Relacionado

Updated: Oct 17, 2025

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
15:13

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange

Published on: April 27, 2017

11.2K

Un retrotransposón específico de ratón impulsa una isoforma Cdk2ap1 conservada esencial para el desarrollo

Andrew J Modzelewski1, Wanqing Shao2, Jingqi Chen1

  • 1Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|October 13, 2021
PubMed
Resumen

Los elementos transponibles, específicamente los promotores de retrotransposón de repetición terminal larga, impulsan la regulación génica durante el desarrollo temprano de los mamíferos. Los promotores de transposones específicos de la especie generan isoformas de proteínas conservadas con nuevas funciones, lo que afecta a la divergencia del desarrollo.

Palabras clave:
Cdk2 y Cdk2Cdk2ap1 y Cdk2ap2Proliferación de las célulasla implantaciónLos mamíferosel ratónEmbriones de preimplantaciónLos promotoresLos retrotransposonesLos transposones

Más Videos Relacionados

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

10.4K
Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.9K

Videos de Experimentos Relacionados

Last Updated: Oct 17, 2025

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange
15:13

Structure-function Studies in Mouse Embryonic Stem Cells Using Recombinase-mediated Cassette Exchange

Published on: April 27, 2017

11.2K
Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

10.4K
Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.9K

Área de la Ciencia:

  • La genómica
  • Biología del desarrollo
  • Biología evolutiva

Sus antecedentes:

  • Los retrotransposones son elementos genéticos móviles que juegan un papel crucial en la regulación génica durante el desarrollo y la enfermedad.
  • Su inducción transitoria durante la embriogénesis temprana sugiere una importancia funcional significativa en todas las especies.

Objetivo del estudio:

  • Caracterizar la inducción transitoria del retrotransposón durante el desarrollo preimplantacional en ocho especies de mamíferos.
  • Investigar el papel de la regulación génica impulsada por retrotransposones en la divergencia evolutiva de los mamíferos.

Principales métodos:

  • Análisis comparativo de la actividad del retrotransposón en ocho especies de mamíferos durante el desarrollo preimplantacional.
  • Caracterización funcional de un promotor de retrotransposón MT2B2 específico para ratones y su papel en la regulación de Cdk2ap1.
  • Investigación de la conservación evolutiva y la expresión específica de las isoformas de Cdk2ap1.

Principales resultados:

  • Las retrotransposones inducidas muestran perfiles de preimplantación conservados y funciones reguladoras, particularmente a través de promotores de repetición terminal larga (RTL).
  • Un promotor de retrotransposón MT2B2 de ratón genera un Cdk2ap1 truncado (Cdk2ap1 ΔN) esencial para la proliferación preimplantación y la implantación de embriones.
  • Cdk2ap1ΔN se conserva en la secuencia y la función, pero es impulsado por diferentes promotores en los mamíferos, con una expresión correlacionada con la duración del desarrollo preimplantación.

Conclusiones:

  • Los promotores de transposones específicos de la especie pueden generar isoformas de proteínas conservadas evolutivamente con funciones nuevas y específicas de la especie.
  • Este mecanismo contribuye a la divergencia biológica esencial y la adaptación durante la evolución de los mamíferos.
  • Los elementos reguladores derivados del retrotransposón son críticos para orquestar las trayectorias de desarrollo específicas de la especie.