Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Chemical Synapses01:26

Chemical Synapses

9.8K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
9.8K
Synaptic Signaling01:09

Synaptic Signaling

5.9K
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
5.9K
The Synapse02:47

The Synapse

129.0K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
129.0K
Overview of Synapses01:25

Overview of Synapses

3.4K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
3.4K
Integration of Synaptic Events01:28

Integration of Synaptic Events

2.4K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
2.4K
Excitatory and Inhibitory Effects of Neurotransmitters01:29

Excitatory and Inhibitory Effects of Neurotransmitters

11.4K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
11.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Understanding Clinicians' Perspectives on End-of-Life Dreams and Visions: An International Survey.

Journal of palliative medicine·2026
Same author

AETA peptide contributes to Alzheimer's disease signature of synapse dysfunction.

Acta neuropathologica·2026
Same author

Implementation of a Complementary and Integrative Medicine Service on a Palliative Care Unit of a Tertiary Care Center in Switzerland.

Journal of palliative medicine·2026
Same author

A Proline-Rich-Domain-Binding Single Domain Antibody Selectively Inhibits RNA-Induced Phase Separation of Tau.

ACS chemical neuroscience·2026
Same author

Spiritual needs in palliative care inpatients: a four-year analysis of clinical data from a tertiary care center.

BMC palliative care·2026
Same author

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease.

Translational neurodegeneration·2026
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Oct 14, 2025

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

11.6K

Estabilización de las sinapsis

David Blum1, Luísa V Lopes2

  • 1Lille Neuroscience & Cognition, Inserm UMR-S1172, Alzheimer & Tauopathies, LabEx DISTALZ, Lille Cedex, France.

Science (New York, N.Y.)
|November 4, 2021
PubMed
Resumen
Este resumen es generado por máquina.

La adenosina juega un papel clave en la formación de nuevas conexiones cerebrales durante el desarrollo. Esta molécula ayuda a determinar la estructura final y la función de las sinapsis nacientes.

Más Videos Relacionados

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
09:33

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

Published on: June 26, 2018

7.6K
Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

17.5K

Videos de Experimentos Relacionados

Last Updated: Oct 14, 2025

Presynaptically Silent Synapses Studied with Light Microscopy
11:02

Presynaptically Silent Synapses Studied with Light Microscopy

Published on: January 4, 2010

11.6K
An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins
09:33

An Optical Assay for Synaptic Vesicle Recycling in Cultured Neurons Overexpressing Presynaptic Proteins

Published on: June 26, 2018

7.6K
Evaluation of Synapse Density in Hippocampal Rodent Brain Slices
07:44

Evaluation of Synapse Density in Hippocampal Rodent Brain Slices

Published on: October 6, 2017

17.5K

Área de la Ciencia:

  • La neurociencia
  • Biología del desarrollo
  • Biología molecular

Sus antecedentes:

  • La formación de sinapsis es un proceso crítico durante el desarrollo del cerebro.
  • Los mecanismos precisos que regulan la maduración y la estabilización de las sinapsis no se comprenden completamente.
  • Se sabe que la adenosina, un neuromodulador, influye en la actividad neuronal.

Objetivo del estudio:

  • Para investigar el papel de la adenosina en la regulación de las sinapsis nacientes.
  • Para aclarar cómo la señalización de la adenosina impacta el desarrollo y la plasticidad de las sinapsis.

Principales métodos:

  • Se utilizaron modelos in vivo e in vitro del desarrollo cerebral.
  • Empleó manipulación genética para alterar las vías de señalización de la adenosina.
  • Realizó grabaciones electrofisiológicas y técnicas avanzadas de imagen para evaluar la función y la estructura sináptica.

Principales resultados:

  • Se encontró que la señalización de la adenosina es crucial para la estabilización de las sinapsis recién formadas.
  • Se identificaron subtipos específicos de receptores de adenosina como mediadores clave de este proceso.
  • La interrupción de la señalización de la adenosina condujo a un desarrollo sináptico aberrante y a una actividad alterada de la red neuronal.

Conclusiones:

  • La adenosina actúa como un regulador crítico del desarrollo de las sinapsis, influyendo en su destino a largo plazo.
  • La orientación de las vías de adenosina puede ofrecer nuevas estrategias terapéuticas para los trastornos del desarrollo neurológico que afectan la función sináptica.