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Patrones fuera de equilibrio fototriggerados controlados espacialmente de nanofibras de péptidos en un hidrogel de

Keisuke Nakamura¹, Wataru Tanaka¹, Kei Sada¹

¹Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.

Journal of the American Chemical Society

|November 12, 2021

Resumen

Los investigadores crearon patrones desencadenados por la luz en hidrogeles utilizando nanofibras fotorresponsivas. Este método controla el autoensamblaje del material para nuevas estructuras fuera de equilibrio.

Área de la Ciencia:

Ciencias de los materiales
Química supramolecular
Ingeniería de Biomateriales

Sus antecedentes:

Los patrones fuera de equilibrio son comunes en la naturaleza pero poco explorados en materiales artificiales.
Los procesos de difusión impulsan la formación de patrones, ofreciendo oportunidades para el diseño de materiales.
Los materiales fotorreactivos permiten cambios dinámicos controlados por la luz.

Objetivo del estudio:

Para demostrar la formación de patrones fototriggerados fuera de equilibrio.
Para utilizar nanofibras basadas en péptidos fotorresponsivos dentro de un sistema de hidrogel.
Para controlar el montaje supramolecular usando luz y difusión.

Principales métodos:

Irradiación de un hidrogel de doble red autoclasificador que contiene nanofibras de péptido utilizando una fotomasca.
Condensación controlada espacialmente inducida por la luz y posterior incubación térmica.
Imágenes confocales y análisis espectroscópico para observar la foto descomposición y la reconstitución.

Principales resultados:

Las nanofibras metastables se fotocomponen en las zonas irradiadas.
Nanofibras termodinámicamente estables reconstituidas y condensadas utilizando monómeros de áreas no irradiadas.
Creación de patrones únicos fuera de equilibrio, incluyendo formaciones de líneas complejas y inmovilización de proteínas.

Conclusiones:

La luz y la difusión pueden regular los eventos supramoleculares para la formación de patrones.
Las nanofibras fotorresponsivas en hidrogeles ofrecen una plataforma versátil para crear estructuras de materiales dinámicos y no equilibrados.
Este enfoque permite un control espacial preciso sobre el montaje y la función del material.

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