La O-glucosilación induce a la amiloide-β a formar nuevos polimorfos de fibrillas vulnerables a la degradación

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Updated: Oct 11, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

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Dangliang Liu1,2, Qijia Wei1,2, Wencheng Xia3,4

  • 1State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.

Journal of the American Chemical Society
|November 29, 2021
PubMed
Resumen

La O-glucosilación de los péptidos amiloide-beta (Aβ) tiene un impacto en la progresión de la enfermedad de Alzheimer (EA). Este estudio revela cómo los O-glicanos específicos alteran la agregación y degradación de Aβ, ofreciendo nuevos conocimientos sobre la patogénesis de la EA.

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