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Updated: Oct 10, 2025

Detection of Detergent-sensitive Interactions Between Membrane Proteins
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Bases estructurales de la inhibición del transportador humano de glucosa SGLT2-MAP17

Yange Niu1, Rui Liu1, Chengcheng Guan1

  • 1State Key Laboratory of Membrane Biology, College of Future Technology, Institute of Molecular Medicine, Peking University, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Beijing, China.

Nature
|December 9, 2021
PubMed
Resumen

La estructura del cotransportador humano de sodio-glucosa 2 (hSGLT2) unido a la empagliflozina se determinó mediante el uso de cryo-EM. Esto revela cómo la empagliflozina inhibe la hSGLT2, ofreciendo ideas para nuevos tratamientos de la diabetes tipo 2.

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