Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

4.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
4.3K
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

896
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
896
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.9K
Brainstem: Control Centers of Medulla01:21

Brainstem: Control Centers of Medulla

2.5K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
2.5K
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

3.3K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
3.3K
Neural Circuits01:25

Neural Circuits

1.8K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.8K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

MODELING TRAJECTORIES USING FUNCTIONAL LINEAR DIFFERENTIAL EQUATIONS.

The annals of applied statistics·2025
Same author

Genetically identified amygdala-striatal circuits for valence-specific behaviors.

Nature neuroscience·2021
Same author

A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.

Cell·2020
Same author

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.

Science (New York, N.Y.)·2019
Same author

Plants' use of different nitrogen forms in response to crude oil contamination.

Environmental pollution (Barking, Essex : 1987)·2010
Same author

Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis.

Journal of the neurological sciences·2010

Video Experimental Relacionado

Updated: Oct 10, 2025

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
10:05

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

14.5K

Un circuito de tronco cerebral definido genéticamente controla selectivamente el vigor motivacional

Hanfei Deng1, Xiong Xiao1, Tao Yang1

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Cell
|December 10, 2021
PubMed
Resumen

La corteza insular anterior (AIC) señala el vigor motivacional a través de las neuronas Fezf2, influyendo en el comportamiento de búsqueda de necesidades. Este circuito regula el esfuerzo y la liberación de dopamina, pero no el gusto o el consumo.

Palabras clave:
Fezf2Las NTSalCCorteza insular anteriorLa dopamina tambiénesfuerzoImágenesLa motivaciónNúcleo del tracto solitarioOptogenéticaneuronas del tracto piramidalel vigor

Más Videos Relacionados

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

23.8K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K

Videos de Experimentos Relacionados

Last Updated: Oct 10, 2025

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
10:05

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

14.5K
Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

23.8K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K

Área de la Ciencia:

  • La neurociencia
  • Neurociencia del comportamiento
  • La toma de decisiones

Sus antecedentes:

  • La corteza insular anterior (AIC) es crucial para el control del comportamiento, sin embargo, sus mecanismos neuronales precisos no se comprenden completamente.
  • Las neuronas del tracto piramidal dentro del AIC están implicadas en los procesos cognitivos y motivacionales.

Objetivo del estudio:

  • Para aclarar los mecanismos neuronales por los cuales el AIC controla el vigor motivacional y el comportamiento de búsqueda de necesidades.
  • Identificar poblaciones y circuitos neuronales específicos involucrados en la regulación de las acciones motivadas.

Principales métodos:

  • Utilizó el etiquetado genético para identificar y dirigirse a las neuronas que expresan Fezf2 en el aIC (aICFezf2).
  • Investigación de la actividad neuronal y de las proyecciones del circuito desde el AIC al núcleo del tracto solitario (NTS).
  • Examinó el papel del circuito aIC → NTS en el control del comportamiento, la liberación de dopamina y el consumo.

Principales resultados:

  • Las neuronas aIC Fezf2 señalan el vigor motivacional y vigorizan el comportamiento de búsqueda de necesidades a través de proyecciones al NTS.
  • La actividad anticipatoria en las neuronas Fezf2 y NTS, adquirida a través del aprendizaje, codifica el valor percibido y el vigor de acción para las necesidades homeostáticas.
  • El circuito aIC → NTS controla selectivamente el vigor, el esfuerzo y la liberación de dopamina estriatal, dependiendo de las acciones y necesidades aprendidas.
  • aICFezf2 neuronas no representan el gusto o la valencia, ni el refuerzo de la unidad de circuito o el consumo total.

Conclusiones:

  • Funciones específicas del circuito aIC → NTS en el control del vigor motivacional.
  • Sugiere que la motivación está mediada en parte por la regulación de arriba hacia abajo de la señalización de la dopamina.
  • Destaca el papel de poblaciones neuronales específicas en el aIC para regular el comportamiento motivado.