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Proteínas, proteínas en todas partes
1H. Holden Thorp Editor-in-Chief, Science journals.
Resumen
Los científicos han resuelto el problema del plegamiento de las proteínas, que lleva décadas, prediciendo la estructura de las proteínas a partir de las secuencias de aminoácidos. Este avance abre nuevas posibilidades para comprender la función de las proteínas y las enfermedades.
Área de la Ciencia:
- La bioquímica
- Biología estructural
- Química bioorgánica
Sus antecedentes:
- El problema del plegamiento de proteínas, que buscaba predecir la estructura 3D de una proteína a partir de su secuencia de aminoácidos, ha sido un desafío central en la biología molecular desde mediados del siglo XX.
- Los primeros trabajos de Kendrew y Perutz sobre las estructuras de la mioglobina y la hemoglobina en 1957, y la hipótesis de estabilidad termodinámica de Anfinsen, sentaron las bases para comprender la estructura de las proteínas.
- A pesar de los avances significativos, predecir con precisión la estructura de la proteína únicamente a partir de la secuencia siguió siendo difícil durante décadas.
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