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La infección por SARS-CoV-2 desencadena respuestas profibróticas de los macrófagos y fibrosis pulmonar

Daniel Wendisch1, Oliver Dietrich2, Tommaso Mari3

  • 1Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.

Cell
|December 16, 2021
PubMed
Resumen

El COVID-19 severo causa síndrome de dificultad respiratoria aguda (SRAP) al activar los macrófagos profibróticos, lo que lleva a la fibrosis pulmonar. Este estudio revela que el SARS-CoV-2 induce directamente estas respuestas fibróticas en los macrófagos.

Palabras clave:
ARDS y sus derivadosEl COVID-19El IPFEn el caso del SARS-CoV-2Fibrosis en el cuerpoel pulmónLos macrófagosLos monocitosProteomíaFibrosis pulmonartranscriptómica de una sola célula

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