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Los inhibidores de la OGA picomólicos permiten el mapeo quimioproteómico de sus modificaciones post-traducionales

Manuel González-Cuesta1, Peter Sidhu2,3, Roger A Ashmus2

  • 1Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, 41012 Sevilla, Spain.

Journal of the American Chemical Society
|January 5, 2022
PubMed
Resumen

Los nuevos inhibidores bicíclicos de tiazolidina ofrecen un control preciso sobre la O-GlcNAcase (OGA), una enzima clave en la vía O-GlcNAc. Estos potentes inhibidores de la OGA y las sondas quimioproteómicas avanzan en la investigación de la modificación de proteínas y la regulación celular.

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