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Especificación dependiente de la visión de los tipos de células y la función en la corteza en desarrollo

Sarah Cheng1, Salwan Butrus2, Liming Tan3

  • 1Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell
|January 22, 2022
PubMed
Resumen
Este resumen es generado por máquina.

La visión da forma a tipos específicos de células cerebrales en las capas superiores de la corteza visual del ratón (V1). Este desarrollo dependiente de la experiencia se basa en la expresión génica, lo que afecta la forma en que las neuronas se conectan y funcionan.

Palabras clave:
La visión binocularTipo de célulaperíodo críticoSinapsis inhibidorasCapa 2/3ARN secuencial de un solo núcleoLa corteza visual

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Área de la Ciencia:

  • La neurociencia
  • Biología del desarrollo
  • La genética

Sus antecedentes:

  • La experiencia postnatal influye significativamente en el desarrollo del cerebro, particularmente en los circuitos corticales.
  • Comprender las trayectorias de desarrollo específicas del tipo de célula en respuesta a la información sensorial sigue siendo un desafío.

Objetivo del estudio:

  • Investigar cómo la experiencia visual da forma a distintos tipos de células en la corteza visual primaria del ratón (V1).
  • Identificar los mecanismos moleculares subyacentes al refinamiento del circuito dependiente de la experiencia.

Principales métodos:

  • Secuenciación de ARN de un solo núcleo para perfilar los tipos de células.
  • La privación visual y la manipulación genética para evaluar cambios dependientes de la experiencia.
  • Imágenes funcionales para evaluar las respuestas neuronales.

Principales resultados:

  • La visión impulsa selectivamente la especificación de los tipos de células glutamatérgicas de la capa superior (L2/3/4).
  • Se establecen tipos de células glutamatérgicas, GABAérgicas y no neuronales de capa más profunda antes de la apertura del ojo.
  • La expresión génica dependiente de la experiencia, incluida Igsf9b, regula la adhesión celular y la formación de sinapsis en L2/3.
  • Igsf9b es crucial para el desarrollo normal de la respuesta binocular en L2/3.

Conclusiones:

  • La entrada visual regula preferentemente el desarrollo de los tipos de células glutamatérgicas de la capa superior.
  • Los programas de expresión génica específicos del tipo de célula son mediadores clave del desarrollo cortical dependiente de la experiencia visual.