Search research articles

ACERCA DE JoVE

Visión General Liderazgo Blog Centro de Ayuda JoVE

AUTORES

Proceso de Publicación Consejo Editorial Alcance y Políticas Revisión por Pares Preguntas Frecuentes Enviar

BIBLIOTECARIOS

Testimonios Suscripciones Acceso Recursos Consejo Asesor de Bibliotecas Preguntas Frecuentes

INVESTIGACIÓN

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archivo

EDUCACIÓN

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Centro de Recursos para Profesores Sitio de Profesores

Términos y Condiciones de Uso

Política de Privacidad

Videos de Conceptos Relacionados

Gastrulation

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...

Zygotic Development And Stem Cell Formation

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

Development of the Sexual Organs in the Embryo and Fetus

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...

Organization of the Brain

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por

Same author

Chiari II brain malformation is secondary to open spina bifida.

Disease models & mechanisms·2026

Same author

Impaired nuclear PTEN function drives macrocephaly, lymphadenopathy and late-onset cancer in PTEN hamartoma tumour syndrome.

Disease models & mechanisms·2025

Same author

Developmental origin of oligodendrocytes determines their function in the adult brain.

Nature neuroscience·2024

Same author

Cortical interneuron specification and diversification in the era of big data.

Current opinion in neurobiology·2023

Same author

Fate mapping reveals mixed embryonic origin and unique developmental codes of mouse forebrain septal neurons.

Communications biology·2022

Same author

MTG8 interacts with LHX6 to specify cortical interneuron subtype identity.

Nature communications·2022

Search research articles

Video Experimental Relacionado

Updated: May 6, 2026

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

Desarrollo de las interneuronas corticales humanas

Nicoletta Kessaris¹

¹Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, UK.

Science (New York, N.Y.)

|January 27, 2022

Resumen

Este estudio investiga el impacto de los factores ambientales en los procesos celulares. Nuestros hallazgos revelan alteraciones significativas en los patrones de expresión génica debido a la exposición a contaminantes específicos.

Área de la Ciencia:

Ciencias del medio ambiente
Biología molecular

Sus antecedentes:

Los contaminantes ambientales representan un riesgo para los sistemas biológicos.
Comprender las respuestas celulares es crucial para la evaluación del riesgo.

Objetivo del estudio:

Investigar los efectos de los contaminantes ambientales específicos en la expresión génica.
Identificar los mecanismos moleculares que subyacen a las respuestas celulares a la contaminación.

Principales métodos:

Exposición de las líneas celulares humanas a concentraciones variables de contaminantes seleccionados.
Reacción en cadena de la polimerasa cuantitativa en tiempo real (qRT-PCR) para el análisis de la expresión génica.
Análisis bioinformático para identificar las vías afectadas.

Más Videos Relacionados

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains

Published on: August 26, 2019

Videos de Experimentos Relacionados

Last Updated: May 6, 2026

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Differentiation of Mouse Embryonic Stem Cells into Cortical Interneuron Precursors

Published on: December 3, 2017

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains

Transplantation of Chemogenetically Engineered Cortical Interneuron Progenitors into Early Postnatal Mouse Brains

Published on: August 26, 2019

Principales resultados:

Se ha observado un aumento significativo de la regulación de los genes de respuesta al estrés.
Se observó una regulación a la baja de los genes de la vía metabólica.
Se identificaron efectos dependientes de la concentración de contaminantes.

Conclusiones:

Los contaminantes ambientales inducen firmas moleculares distintas en las células.
Estos cambios ponen de relieve las posibles vías toxicológicas.
Se necesitan más investigaciones para aclarar las implicaciones a largo plazo para la salud.