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Efectos de la milrinona en el rendimiento ventricular izquierdo y la contractilidad miocárdica en pacientes con
Circulation
|March 1, 1986
Resumen
La milrinona, un derivado de la bipiridina, demuestra un efecto inotrópico positivo en la contractilidad miocárdica, a pesar de sus potentes propiedades vasodilatadoras. Este estudio aclara su impacto en la función cardíaca en pacientes con disfunción ventricular.
Área de la Ciencia:
- Cardiología Cardiología.
- Farmacología Farmacología.
Sus antecedentes:
- Los derivados de la bipiridina poseen potentes propiedades vasodilatadoras, lo que complica la evaluación de sus efectos inotrópicos.
- Estudios anteriores han demostrado inconsistentemente la acción inotrópica positiva de estos agentes en pacientes con disfunción ventricular.
Objetivo del estudio:
- Para investigar los efectos de la dosis-respuesta de la milrinona intravenosa en la contractilidad miocárdica.
- Para evaluar estos efectos en conjunción con los cambios en la presión de llenado ventricular.
Principales métodos:
- Se han administrado dosis incrementales de milrinona intravenosa.
- Se midió la contractilidad miocárdica utilizando pico ventricular izquierdo positivo dP/dt.
- Cambios simultáneos monitoreados en la presión de llenado ventricular.
Principales resultados:
- La administración de milrinona dio lugar a un aumento relacionado con la dosis en el pico ventricular izquierdo positivo dP/dt en 6 de 11 pacientes.
- El pico ventricular izquierdo positivo dP/dt se mantuvo sin cambios en 4 pacientes y disminuyó en 1 paciente.
- Todos los pacientes experimentaron una reducción significativa en la presión de llenado del ventrículo izquierdo.
Conclusiones:
- La milrinona exhibe un efecto inotrópico distinto.
- Este efecto inotrópico está presente junto con sus significativas propiedades vasodilatadoras.
- El estudio aclara la doble acción de la milrinona en la función cardíaca.
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