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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
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Efectos de las mezclas químicas en la salud humana
Zeyan Liew1,2, Pengfei Guo1,2
1Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.
Science (New York, N.Y.)
|February 17, 2022
Resumen
Las sustancias químicas que alteran el sistema endocrino suponen un riesgo para el desarrollo neurológico del niño. La exposición puede afectar negativamente los resultados cognitivos y conductuales en los niños.
Área de la Ciencia:
- Salud del medio ambiente
- La neurociencia
- Toxicología
Sus antecedentes:
- Los disruptores endocrinos son sustancias exógenas que interfieren con los sistemas hormonales.
- Estas sustancias químicas predominan en el medio ambiente y la exposición humana es generalizada.
- Los efectos adversos en el desarrollo neurológico son una preocupación creciente.
Objetivo del estudio:
- Investigar el impacto de las sustancias químicas que alteran el sistema endocrino en el desarrollo neurológico infantil.
- Identificar los puntos finales específicos del desarrollo neurológico afectados por la exposición a los EDC.
- Informar las estrategias de salud pública para mitigar los riesgos.
Principales métodos:
- Revisión sistemática de los estudios epidemiológicos y de la investigación toxicológica.
- Análisis de los datos de exposición y resultados de la evaluación del desarrollo neurológico.
- Metaanálisis de los hallazgos pertinentes, cuando proceda.
Principales resultados:
- La evidencia sugiere una correlación entre la exposición a los EDC y los déficits del desarrollo neurológico.
- EDCs específicos relacionados con la función cognitiva alterada, la atención y el comportamiento.
- Se están aclarando las relaciones dosis-respuesta y las ventanas críticas de exposición.
Conclusiones:
- Las sustancias químicas que alteran el sistema endocrino representan una amenaza ambiental significativa para el desarrollo neurológico saludable del niño.
- Se necesita más investigación para comprender plenamente los mecanismos y las consecuencias a largo plazo.
- Las intervenciones políticas son cruciales para reducir la exposición a los EDC y proteger la salud de los niños.
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