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Videos de Conceptos Relacionados

What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

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Umbilical Cord-derived Mesenchymal Stem Cells for COVID-19 Patients with Acute Respiratory Distress Syndrome (ARDS).

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Video Experimental Relacionado

Updated: Jul 1, 2026

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
07:53

Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

Published on: January 1, 2018

Modelo de represión génica irreversible para el control del desarrollo.

A I Caplan, C P Ordahl

    Science (New York, N.Y.)
    |July 14, 1978
    PubMed
    Resumen

    Durante el desarrollo embrionario temprano, las células pierden su potencial para convertirse en múltiples tipos de células. Este estudio propone que la represión progresiva de genes, no la activación de genes, impulsa esta restricción irreversible del destino celular.

    Área de la Ciencia:

    • Biología del desarrollo Biología del desarrollo.
    • La diferenciación celular es la diferenciación celular.
    • Regulación genética La regulación genética.

    Sus antecedentes:

    • Las células embrionarias pluripotentes pierden progresivamente el potencial de desarrollo a medida que avanza la diferenciación.
    • La restricción celular a un solo fenotipo es irreversible, pero los mecanismos de transcripción subyacentes no se comprenden completamente.

    Objetivo del estudio:

    • Presentar un modelo que explique la disminución del potencial de desarrollo.
    • Investigar el papel de los cambios en la transcripción génica en la diferenciación y restricción celular.

    Principales métodos:

    • Revisión de las observaciones de embriología experimental.
    • Análisis de datos recientes de experimentación bioquímica.

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    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

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    Videos de Experimentos Relacionados

    Last Updated: Jul 1, 2026

    Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans
    07:53

    Application of RNAi and Heat-shock-induced Transcription Factor Expression to Reprogram Germ Cells to Neurons in C. elegans

    Published on: January 1, 2018

    Inducible and Reversible Dominant-negative (DN) Protein Inhibition
    08:35

    Inducible and Reversible Dominant-negative (DN) Protein Inhibition

    Published on: January 7, 2019

    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
    08:54

    In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression

    Published on: March 29, 2019

  • Desarrollo de un modelo de represión génica.

    • Principales resultados:

    • Se propone un modelo de represión genética progresiva e irreversible.
    • Este modelo es consistente con los datos embriológicos y bioquímicos existentes.
    • La represión genética se presenta como el principal impulsor de la pérdida de potencial de desarrollo.

    Conclusiones:

    • La pérdida del potencial de desarrollo durante la diferenciación resulta de la represión progresiva e irreversible de genes previamente activos.
    • Un esquema de represión genética progresiva proporciona una explicación más consistente que la activación genética selectiva para los eventos de restricción celular observados.