Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
The Cell Cycle Control System01:28

The Cell Cycle Control System

3.7K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.7K
Global Regulatory Systems01:28

Global Regulatory Systems

101
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
101
Combinatorial Gene Control02:33

Combinatorial Gene Control

8.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
8.5K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

4.6K
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
4.6K
General Transcription Factors01:30

General Transcription Factors

5.7K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
5.7K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Expansion-Assisted Hybridization Chain Reaction-smFISH and Immunohistochemistry in Drosophila Brain.

Journal of visualized experiments : JoVE·2026
Same author

Organization and evolution of sex-biased gene expression in <i>Drosophila</i> adult sexual circuits.

bioRxiv : the preprint server for biology·2026
Same author

Remote and partial clocks expand the circadian neuronal network, driving widespread molecular rhythmicity in <i>Drosophila</i>.

bioRxiv : the preprint server for biology·2026
Same author

Electrical synapses mediate visual approach behavior.

bioRxiv : the preprint server for biology·2025
Same author

Establishing a continuum of cell types in the visual cortex.

bioRxiv : the preprint server for biology·2025
Same author

A Synthetic Phage-Peptide Conjugate as a Potent Antibacterial Agent for <i>Pseudomonas aeruginosa</i> Infections.

ACS central science·2025

Video Experimental Relacionado

Updated: Oct 2, 2025

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
07:59

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Published on: March 22, 2018

7.8K

Un mecanismo de sincronización global regula los programas de cableado específicos del tipo de célula

Saumya Jain1,2, Ying Lin1,3, Yerbol Z Kurmangaliyev2

  • 1Department of Biological Chemistry, University of California, Los Angeles, CA, USA.

Nature
|February 24, 2022
PubMed
Resumen
Este resumen es generado por máquina.

Una hormona esteroide, la ecdisona, controla el tiempo de ensamblaje del circuito neuronal en las moscas mediante la activación de factores de transcripción. Este proceso asegura la especificidad adecuada del cableado y las conexiones sinápticas en el desarrollo de las neuronas.

Más Videos Relacionados

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.6K
Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

12.9K

Videos de Experimentos Relacionados

Last Updated: Oct 2, 2025

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions
07:59

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions

Published on: March 22, 2018

7.8K
Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

22.6K
Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

12.9K

Área de la Ciencia:

  • La neurociencia
  • Biología del desarrollo
  • La genética

Sus antecedentes:

  • El ensamblaje de circuitos neuronales requiere una expresión espacial-temporal precisa de las moléculas de reconocimiento celular.
  • Si bien se conocen los factores de especificidad de tipo celular, los mecanismos que determinan el tiempo de cableado siguen siendo escurridizos.

Objetivo del estudio:

  • Para investigar el papel de las hormonas esteroides en la regulación del tiempo de la formación de circuitos neuronales.
  • Identificar las vías moleculares que controlan la expresión génica espacio-temporal durante el cableado neuronal.

Principales métodos:

  • Se utilizó la secuenciación de una sola célula en las neuronas del sistema visual de Drosophila.
  • Analizó los efectos de la interrupción de la vía de la ecdisona en el desarrollo neuronal y la conectividad.
  • Investigó las relaciones regulatorias entre los factores de transcripción y los genes de cableado.

Principales resultados:

  • La ecdisona induce una cascada de factores de transcripción en todas las neuronas del sistema visual, regulando la maduración sináptica y la especificidad del cableado.
  • Objetivos comunes y específicos del tipo de célula de la vía de la ecdisona, incluidas las proteínas de la superficie celular.
  • Demostró que el orden de expresión del factor de transcripción se correlaciona con eventos secuenciales de cableado, y la interrupción causa defectos específicos de desarrollo.

Conclusiones:

  • Las neuronas integran un módulo transcripcional temporal global (vía ecdisona) con factores específicos del tipo de célula para lograr un cableado preciso.
  • Este sistema integrado genera patrones específicos del tipo celular de moléculas de reconocimiento celular esenciales para la formación precisa de circuitos neuronales.