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The human X chromosome contains over ten times the number of genes as in the Y chromosome. Since males have only one X chromosome, and females have two, one might expect females to produce twice as many of the proteins, with undesirable results.
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The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence categorization, a person will feel...
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Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
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Published on: December 20, 2019

C. Thomas Caskey (1938-2022) fue un

Andrea Ballabio1,2,3,4, Huda Zoghbi3,4,5

  • 1Telethon Institute of Genetics and Medicine, Pozzuoli, Italy.

Science (New York, N.Y.)
|February 24, 2022
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio destaca una figura clave en la medicina genómica. Su trabajo ha avanzado significativamente en el campo de la atención médica personalizada y las terapias genéticas.

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Área de la Ciencia:

  • Medicina genómica
  • Atención médica personalizada

Sus antecedentes:

  • El campo de la medicina genómica está evolucionando rápidamente.
  • Comprender las contribuciones de los investigadores clave es crucial para el seguimiento del progreso científico.

Objetivo del estudio:

  • Reconocer y detallar las contribuciones significativas de un arquitecto líder en medicina genómica.
  • Subrayar el impacto de su trabajo visionario en el avance de las terapias genéticas y la atención médica personalizada.

Principales métodos:

  • Revisión de las publicaciones fundamentales y las contribuciones a la investigación.
  • Análisis del impacto en la práctica clínica y las direcciones futuras de la investigación.
  • Síntesis biográfica de los hitos de la carrera y las funciones de liderazgo.

Principales resultados:

  • Identificación del individuo como una fuerza fundamental en la configuración de la medicina genómica.
  • Documentación de su papel en el desarrollo de estrategias genómicas diagnósticas y terapéuticas innovadoras.
  • Evidencia de su influencia en la adopción más amplia de conocimientos genómicos en entornos clínicos.

Conclusiones:

  • El enfoque visionario del individuo ha influido profundamente en la trayectoria de la medicina genómica.
  • Su trabajo sirve como un elemento fundamental para los avances en curso en el tratamiento y la prevención de enfermedades genéticas.
  • El reconocimiento continuo de estos pioneros es esencial para inspirar la innovación futura en el campo.