Jove
Visualize
Contáctanos

Videos de Conceptos Relacionados

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

252
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
252
Understanding Sleep01:11

Understanding Sleep

705
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
705
Aging01:26

Aging

246
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
246
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.8K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.8K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.8K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.8K
Bone Disorders01:29

Bone Disorders

4.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Structured Online Support to Inform and Assist Antidepressant Deprescribing in Primary Care: Protocol for a Pragmatic, Randomized Controlled Trial (The WiserAD Trial).

JMIR research protocols·2026
Same author

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.

British journal of pharmacology·2025
Same author

PS19 mouse tauopathy is associated with sex-dependent sleep loss and hyperarousal, and predicts cognitive performance.

Neurobiology of aging·2025
Same author

Waking up to the evidence of pharmacological treatments used to manage sleep disorders in people with dementia and mild cognitive impairment-A scoping review.

Pharmacological reviews·2025
Same author

Characterization of locus coeruleus neuronal properties with aging in two mouse models of tauopathy.

Journal of Alzheimer's disease : JAD·2025
Same author

Fulminant myocarditis: outcome predictors in an international cohort study.

European heart journal·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Video Experimental Relacionado

Updated: Oct 2, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.6K

Pérdida de sueño con la edad

Laura H Jacobson1,2,3, Daniel Hoyer1,2,4

  • 1Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

Science (New York, N.Y.)
|February 24, 2022
PubMed
Resumen
Este resumen es generado por máquina.

A medida que envejecemos, el aumento de la actividad en las neuronas de hipocretina interrumpe la calidad del sueño. Esta hiperexcitabilidad neuronal es un factor clave en los trastornos del sueño relacionados con la edad.

Más Videos Relacionados

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

1.9K
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.4K

Videos de Experimentos Relacionados

Last Updated: Oct 2, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.6K
Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

1.9K
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.4K

Área de la Ciencia:

  • La neurociencia
  • Ciencia del sueño
  • Investigación sobre el envejecimiento

Sus antecedentes:

  • La calidad del sueño disminuye naturalmente con la edad.
  • Las neuronas de hipocretina (orexina) juegan un papel crucial en la regulación de los ciclos de sueño-vigilia.
  • La desregulación de la señalización de la hipocretina se ha implicado en varios trastornos del sueño.

Objetivo del estudio:

  • Investigar el papel de la actividad neuronal de la hipocretina en las alteraciones del sueño relacionadas con la edad.
  • Determinar si la hiperexcitabilidad de las neuronas de hipocretina es un factor causal en la disminución de la calidad del sueño durante el envejecimiento.

Principales métodos:

  • Registros electrofisiológicos en cortes de cerebro de sujetos jóvenes y ancianos.
  • Manipulación farmacológica de la actividad neuronal de la hipocretina.
  • Análisis del comportamiento de los patrones de sueño en modelos de edad.

Principales resultados:

  • Las neuronas de hipocretina presentan tasas de disparo y excitabilidad significativamente mayores en sujetos mayores en comparación con los más jóvenes.
  • La reducción farmacológica de la excitabilidad de las neuronas hipocretinas restableció parcialmente los patrones normales de sueño en modelos de edad avanzada.
  • El aumento de la señalización de hipocretina se correlacionó con una reducción de la duración del sueño no REM y un aumento de la vigilia.

Conclusiones:

  • La hiperexcitabilidad de las neuronas de hipocretina es un mecanismo principal que contribuye a la alteración de la calidad del sueño en el envejecimiento.
  • La orientación de la señalización de la hipocretina puede ofrecer estrategias terapéuticas para los trastornos del sueño relacionados con la edad.