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Los virus arqueos en forma de huso evolucionaron de antepasados en forma de varilla para empacar un genoma más grande
Fengbin Wang1, Virginija Cvirkaite-Krupovic2, Matthijn Vos3
1Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903, USA.
Cell
|March 24, 2022
Resumen
Los estudios estructurales de los virus en forma de huso que infectan a las arqueas revelan cómo se expanden sus cápsidas helicoidales. Esta investigación sobre el Sulfolobus monocaudavirus 1 explica la evolución viral y los mecanismos de envasado del genoma.
Área de la Ciencia:
- Biología estructural
- Virología
- Arqueas
Sus antecedentes:
- Los virus en forma de huso o limón infectan a las arqueas en diversos entornos.
- Los estudios estructurales de estos viriones pleomórficos son desafiantes debido a su morfología compleja.
- El sulfolobus monocaudavirus 1 infecta a los huéspedes arqueos en entornos extremos, altamente ácidos y de alta temperatura.
Objetivo del estudio:
- Determinar la estructura atómica de la cápside del monocaudavirus Sulfolobus 1.
- Comprender el mecanismo de variación del diámetro en conjuntos virales helicoidales.
- Elucidar los orígenes evolutivos de los virus arqueos en forma de huso.
Principales métodos:
- Determinación de la estructura atómica de la cápside viral.
- Análisis de las interacciones de las subunidades de proteínas y la dinámica de ensamblaje.
- Análisis comparativo de las estructuras virales y las vías evolutivas.
Principales resultados:
- La cápside está formada por una proteína altamente hidrofóbica con subunidades de 7 hebras.
- Las interacciones casi equivalentes permiten cambios significativos en el diámetro de los conjuntos helicoidales.
- Se observaron pasos discretos en la expansión del tubo de cola debido a las interacciones de subunidades conservadas.
Conclusiones:
- Los ensamblajes helicoidales pueden variar de diámetro, lo que permite formas esféricas para el empaque de genomas más grandes.
- Los hallazgos sugieren que los virus en forma de huso evolucionaron a partir de virus parecidos a las varillas de los arqueos.
- Este estudio proporciona información sobre la adaptabilidad estructural y la evolución de los virus arqueos.
Palabras clave:
Capsidos y sus derivadosCrio-EMLos extremófilosPolímeros helicoidalesEvolución del virusMás Videos Relacionados
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