Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

119
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
119
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

50
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
50
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

55
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
55
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

57
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
57
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

78
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
78
Inflammation01:38

Inflammation

55.6K
Overview
55.6K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Primary-Level Meta-Analysis of Diversity Outbred Mice Identifies a Fasting Plasma Trimethylamine N-Oxide (TMAO) Locus Modified by Sex and Diet.

bioRxiv : the preprint server for biology·2026
Same author

ENPP1 blockade with a humanized monoclonal antibody enhances renal repair after acute kidney injury.

Cell stem cell·2026
Same author

Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) maintains muscle progenitor identity by stabilizing the Ppp1r1b-lncRNA-PRC2 complex.

Nucleic acids research·2026
Same author

A liver-heart endocrine axis revealed by systems genetics and mediated by hepatocyte growth factor activator.

medRxiv : the preprint server for health sciences·2026
Same author

p21<sup>+</sup>TREM2<sup>+</sup> senescent macrophages fuel inflammaging and metabolic dysfunction-associated steatotic liver disease.

Nature aging·2026
Same author

Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel.

BMC genomics·2026

Video Experimental Relacionado

Updated: Sep 24, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.3K

Aterosclerosis: desarrollos recientes

Johan L M Björkegren1, Aldons J Lusis2

  • 1Department of Genetics and Genomic Sciences, Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Cell
|May 3, 2022
PubMed
Resumen

La aterosclerosis, una de las principales causas de enfermedades cardiovasculares y accidentes cerebrovasculares, implica procesos inflamatorios complejos. Investigaciones recientes revelan nuevos conocimientos sobre la diversidad celular, el envejecimiento y las influencias del microbioma intestinal en esta enfermedad arterial.

Más Videos Relacionados

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.4K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.1K

Videos de Experimentos Relacionados

Last Updated: Sep 24, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

13.3K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.4K
Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

1.1K

Área de la Ciencia:

  • Ciencias cardiovasculares
  • Biología de la inflamación
  • Genética y genómica

Sus antecedentes:

  • La aterosclerosis es un factor primario de enfermedad cardiovascular (ECV) y accidente cerebrovascular.
  • Se caracteriza como una condición inflamatoria que afecta a las arterias grandes.
  • Comprender sus orígenes multifactoriales es crucial para la prevención y el tratamiento efectivos.

Objetivo del estudio:

  • Revisar los conocimientos actuales sobre los factores moleculares, celulares, genéticos y ambientales que contribuyen a la aterosclerosis.
  • Para resaltar los avances recientes y los descubrimientos biológicos inesperados en el campo.
  • Sintetizar los hallazgos tanto desde el punto de vista de las vías individuales como de la biología de los sistemas.

Principales métodos:

  • Revisión de la literatura de los desarrollos científicos recientes en la investigación de la aterosclerosis.
  • Análisis de las contribuciones moleculares, celulares, genéticas y ambientales.
  • Integración de los hallazgos de las vías individuales y las perspectivas de los sistemas.

Principales resultados:

  • Identificación de una heterogeneidad previamente no reconocida en las células inflamatorias y del músculo liso dentro de las lesiones ateroscleróticas.
  • Elucidación de las funciones de la senescencia celular y la hematopoyesis clonal en la progresión de la enfermedad.
  • Establecimiento de nuevos vínculos entre el microbioma intestinal y el desarrollo de la aterosclerosis.

Conclusiones:

  • La aterosclerosis es una enfermedad inflamatoria compleja con diversos fundamentos celulares y moleculares.
  • Las investigaciones emergentes destacan la importancia del envejecimiento celular, la expansión clonal y las interacciones microbianas.
  • Un enfoque sistémico integral es esencial para comprender y combatir plenamente la aterosclerosis.