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Los leucocitos y el riesgo de enfermedades isquémicas
JAMA
|May 1, 1987
Resumen
Un alto recuento de glóbulos blancos (WBC), incluso dentro del rango normal, aumenta significativamente el riesgo de ataque cardíaco y accidente cerebrovascular. Este hallazgo sugiere que el recuento de glóbulos blancos es un predictor importante y subutilizado de la enfermedad aterosclerótica.
Área de la Ciencia:
- Medicina Cardiovascular La medicina cardiovascular es una especialidad de la salud.
- Hematología Hematología.
- Epidemiología La epidemiología.
Sus antecedentes:
- Los modelos actuales de predicción del riesgo aterosclerótico están incompletos.
- El recuento de glóbulos blancos (WBC) es un predictor potencial y poco reconocido de eventos cardiovasculares.
- Los recuentos elevados de glóbulos blancos se correlacionan con un mayor riesgo de infarto de miocardio y accidente cerebrovascular.
Objetivo del estudio:
- Para investigar la asociación entre el recuento de glóbulos blancos y el riesgo de enfermedad aterosclerótica.
- Explorar el potencial del recuento de glóbulos blancos como un factor predictivo de eventos cardiovasculares.
Principales métodos:
- Análisis epidemiológico de los recuentos de glóbulos blancos en relación con el riesgo de infarto de miocardio y accidente cerebrovascular.
- Examen de la correlación entre un recuento alto de glóbulos blancos normales y el riesgo de eventos cardiovasculares.
- La consideración del recuento de neutrófilos como un tipo específico de glóbulos blancos asociado con el riesgo.
Principales resultados:
- Las personas con recuentos de glóbulos blancos normales altos (> 9000/microL) tienen aproximadamente cuatro veces el riesgo de infarto agudo de miocardio en comparación con aquellos con recuentos bajos normales (<6000/microL).
- El tabaquismo explica solo el 50%-65% de este exceso de riesgo, lo que indica que hay otros factores involucrados.
- Un alto recuento de glóbulos blancos también predice un mayor riesgo de reinfarto y mortalidad hospitalaria.
Conclusiones:
- El recuento de glóbulos blancos, particularmente el recuento de neutrófilos, es un predictor significativo del riesgo de enfermedad aterosclerótica.
- Los glóbulos blancos influyen en la reología de la sangre y contribuyen a la lesión endotelial, lo que explica su valor predictivo.
- La investigación futura puede refinar la predicción de riesgos mediante la incorporación de marcadores de activación de glóbulos blancos.
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