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OCA-T1 y OCA-T2 son coactivadores de POU2F3 en el linaje celular del mechón

Xiaoli S Wu1,2, Xue-Yan He1, Jonathan J Ipsaro1,3

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.

Nature
|May 16, 2022
PubMed
Resumen

El complejo POU2F3-OCA-T es esencial para la identidad y función de las células del mechón en los tejidos de la mucosa y el cáncer de pulmón de células pequeñas. Este descubrimiento revela un regulador clave del desarrollo de células de toba y un potencial objetivo terapéutico.

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