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Videos de Conceptos Relacionados

RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Types of RNA01:23

Types of RNA

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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RNA Structure01:23

RNA Structure

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The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
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Video Experimental Relacionado

Updated: Sep 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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ARN circulares: Caracterización, funciones celulares y aplicaciones

Chu-Xiao Liu1, Ling-Ling Chen2

  • 1State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China.

Cell
|May 18, 2022
PubMed
Resumen

Los ARN circulares (circRNA) son moléculas versátiles que regulan la expresión génica. Los avances permiten estudiar las funciones del circRNA en los procesos celulares y las posibles aplicaciones biomédicas.

Palabras clave:
El RBPCírculo del ARNProteína de unión al ARNAptamer y sus derivadosAcoplamiento traserocircRNA (en inglés)Aplicación de ARN circularModalidad de ARN circularTerapias de ARN circularestraducción circular del ARNinmunogenicidad

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Identification of Circular RNAs using RNA Sequencing
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Identification of Circular RNAs using RNA Sequencing

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Last Updated: Sep 22, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

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Identification of Circular RNAs using RNA Sequencing
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Área de la Ciencia:

  • Biología molecular
  • La genética
  • La bioquímica

Sus antecedentes:

  • Los ARN circulares (ARNs circulares) se originan a partir del empalme posterior del ARNm precursor.
  • El progreso tecnológico ayuda a estudiar la conformación y la función del circRNA.
  • Los circRNA desempeñan diversas funciones en la regulación celular.

Objetivo del estudio:

  • Revisar los métodos para el estudio de los circRNA.
  • Resumir los conocimientos actuales sobre las funciones reguladoras del circRNA.
  • Para explorar las aplicaciones emergentes de circRNAs.

Principales métodos:

  • Revisión de la literatura actual y los avances tecnológicos en la investigación de circRNA.
  • Análisis de las interacciones de circRNA con ADN, ARN y proteínas.
  • Examen de las funciones del circRNA en la transcripción, el empalme y la traducción.

Principales resultados:

  • Los circRNA modulan la expresión génica a través de varios mecanismos.
  • La localización y las interacciones dictan las funciones circRNA.
  • Los circRNA tienen potencial en aplicaciones terapéuticas y de investigación.

Conclusiones:

  • Los circRNA son reguladores clave con un impacto biológico significativo.
  • Se justifica una mayor investigación sobre los mecanismos y las aplicaciones del circRNA.
  • Los circRNA ofrecen nuevas vías para las intervenciones biomédicas.