JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us
Esta página ha sido traducida por una máquina. Otras páginas pueden seguir apareciendo en inglés. View in English

Los efectos de la microbiota oral en la salud

  • 0Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Clinical Neuroscience (new York, N.y.) +

|

26 de mayo de 2022

|

26 de mayo de 2022

Ver abstracta en PubMed

Resumen

Este resumen es generado por máquina.

La microbiota oral forma biofilms complejos. Estas comunidades microbianas tienen un impacto tanto en la salud bucal local como en el bienestar sistémico general.

Área De La Ciencia

  • Microbiología oral
  • Investigación del microbioma
  • Ciencias dentales

Sus Antecedentes

  • La microbiota oral representa un complejo ecosistema de microorganismos que residen en la boca.
  • Estos microorganismos forman comunidades estructuradas conocidas como biofilms.
  • El microbioma oral juega un papel fundamental en el mantenimiento de la salud bucal local.

Objetivo Del Estudio

  • Investigar la intrincada estructura y función de las biopelículas orales.
  • Comprender el impacto de la microbiota oral en la salud local y sistémica.
  • Para explorar posibles objetivos terapéuticos dentro del microbioma oral.

Principales Métodos

  • Utilizando técnicas avanzadas de secuenciación para caracterizar las comunidades microbianas orales.
  • Empleando microscopía para visualizar la arquitectura de las biopelículas orales.
  • Realización de modelos in vitro e in vivo para evaluar las implicaciones para la salud de la microbiota oral.

Principales Resultados

  • Las biopelículas orales presentan una complejidad estructural y una heterogeneidad significativas.
  • Las composiciones microbianas específicas dentro de las biopelículas están asociadas con las condiciones orales locales.
  • La evidencia sugiere un vínculo entre la disbiosis de la microbiota oral y las enfermedades sistémicas.

Conclusiones

  • La microbiota oral, organizada en biofilms, son determinantes cruciales de la salud bucal.
  • Las alteraciones en el microbioma oral pueden tener consecuencias de largo alcance para la salud sistémica.
  • La investigación adicional sobre el microbioma oral es prometedora para nuevas intervenciones de salud.

Videos de Conceptos Relacionados

Factors Affecting the Risk of Infection 01:26

12.3K

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Defense Mechanism Against Infection 01:26

7.3K

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...

Microorganisms in Medicine and Therapeutics 01:29

389

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

Surface Membrane Barriers 01:18

1.6K

The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...

Bacterial Flora of the Large Intestine 01:29

665

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.

Anatomy of the Intestines 01:23

74.3K

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...