Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis02:29

Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis

11.1K
Overview
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
11.1K
Regioselective Formation of Enolates01:33

Regioselective Formation of Enolates

2.8K
As depicted in the figure below, the unsymmetrical ketones can form two possible enolates:  less substituted or more substituted enolates. Usually, the thermodynamic enolates are formed from the more substituted α-carbon atom, while the kinetic enolates are formed faster by deprotonation from the less substituted position. The thermodynamic enolates have lower energy, so they are  more stable. But the energy required to form kinetic enolates is less.
2.8K
Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization01:13

Intramolecular Claisen Condensation of Dicarboxylic Esters: Dieckmann Cyclization

2.6K
Dieckmann cyclization is an intramolecular Claisen condensation of diesters. The reaction occurs in the presence of a base and generates a cyclic β-ketoester as the final product. Commonly, 1, 6 and 1, 7-diesters are preferred substrates for the reaction since the generated five, and six-membered cyclic β-keto esters are particularly more stable.
2.6K
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry01:29

Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry

4.8K
Diels–Alder reactions between cyclic dienes locked in an s-cis configuration and dienophiles yield bridged bicyclic products.
4.8K
Preparation of Epoxides03:00

Preparation of Epoxides

8.2K
Overview
Epoxides result from alkene oxidation, which can be achieved by a) air, b) peroxy acids, c) hypochlorous acids, and d) halohydrin cyclization.
Epoxidation with Peroxy Acids
Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of...
8.2K
β-Dicarbonyl Compounds via Crossed Claisen Condensations01:18

β-Dicarbonyl Compounds via Crossed Claisen Condensations

3.3K
Crossed Claisen condensations are base-promoted reactions between two different ester molecules producing β-dicarbonyl compounds.  The reaction involving esters, with both containing α hydrogen, results in a mixture of four different products that are difficult to isolate. This reduces the synthetic utility of the reaction.
3.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Mitochondria-related pathogenic genes in acute and chronic kidney disease: a Mendelian randomization study.

Renal failure·2026
Same author

Regulatory role of protein lactylation in tumor metastasis: mechanisms and emerging therapeutic strategies.

Journal of advanced research·2026
Same author

A novel nutritional tool to identify infants at risk of stunting.

Frontiers in pediatrics·2026
Same author

Hypoxia-driven immune resistance to anti-PD-1/PD-L1 therapy: Mechanistic insights and therapeutic opportunities.

Pharmacological research·2026
Same author

From real-world pharmacovigilance data to clinical practice: a geriatric-specific predictive model for immune-related adverse events in lung cancer based on routine clinical indicators.

BMC geriatrics·2026
Same author

Gut microbiota dysbiosis-induced chronic inflammation as a driver of atherosclerosis: cellular crosstalk and host-microbe interactions.

Frontiers in cellular and infection microbiology·2026

Video Experimental Relacionado

Updated: Sep 21, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
12:30

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

9.2K

Formación de éter de diarilo por un dominio de tioesterasa versátil

Qian Wei1, Ze-Ping Wang1, Xiao Zhang1

  • 1College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, People's Republic of China.

Journal of the American Chemical Society
|May 31, 2022
PubMed
Resumen
Este resumen es generado por máquina.

Este estudio revela una nueva vía no oxidativa para la formación enzimática de éter diarilo, utilizando un dominio de tioesterasa de una poliquetida sintasa. Este descubrimiento desafía la comprensión previa de la biosíntesis del éter de diarilo.

Más Videos Relacionados

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

10.9K
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
06:46

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

7.5K

Videos de Experimentos Relacionados

Last Updated: Sep 21, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
12:30

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework

Published on: April 9, 2018

9.2K
Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation
11:09

Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation

Published on: August 1, 2018

10.9K
Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
06:46

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

7.5K

Área de la Ciencia:

  • La bioquímica
  • Enzimología
  • Biosíntesis de productos naturales

Sus antecedentes:

  • Los éteres de diarilo se forman comúnmente a través del acoplamiento oxidativo o la reorganización.
  • La generación enzimática de éter diarilo no ha sido caracterizada anteriormente.
  • La comprensión de nuevas vías de biosíntesis es crucial para el descubrimiento de productos naturales.

Objetivo del estudio:

  • Caracterización de un nuevo mecanismo enzimático para la formación de éter diarilo no oxidativo.
  • Para aclarar el proceso catalítico de un dominio de tioesterasa en la biosíntesis de éter diarilo.
  • Explorar estrategias alternativas para generar compuestos de éter de diarilo.

Principales métodos:

  • Descubrimiento y caracterización de un dominio de tioesterasa (TE) de la poliquetida sintasa no reductora (nrPKS) AN7909.
  • Análisis bioquímicos con sustratos de imitación sintéticos.
  • Mutagénesis dirigida al sitio para sondear el mecanismo catalítico.

Principales resultados:

  • Se identificó un dominio TE que cataliza la formación de éter diarilo a través de una vía no oxidativa.
  • Elucidó un proceso de varios pasos que involucra esterificación, reorganización de Smiles e hidrólisis.
  • Proporcionó conocimientos mecanicistas a través del análisis de mutantes y estudios de sustratos.

Conclusiones:

  • El dominio TE descubierto representa una nueva estrategia enzimática para la biosíntesis del éter de diarilo.
  • Este hallazgo amplía el repertorio conocido de funciones enzimáticas asociadas a la PKS.
  • La vía caracterizada ofrece nuevas vías para la biología sintética y el descubrimiento de fármacos.